摘要
目的探讨睾丸间质细胞瘤的临床病理特点及鉴别诊断方法。方法总结2例睾丸间质细胞瘤患者的临床病理资料并复习文献。2例患者年龄均为27岁。例1因左侧睾丸胀痛不适4个月余，例2因婚后3年不育、查体发现右侧睾丸占位1个月入院。B超分别显示睾丸1．0cm×1．3cm、0．8cm×0．6cm强回声光团，边界锐利。2例均行睾丸肿瘤切除术。结果术中快速冰冻病理诊断为睾丸间质细胞瘤。病理组织学表现为瘤细胞呈团、条索或弥漫分布，体积较大，呈多角形，胞质丰富嗜酸性，边界清楚。免疫组化：波形蛋白，钙结合蛋白和抑制素均阳性。2例术后病理诊断均为睾丸间质细胞瘤。2例术后分别随访17、9个月未见复发。结论睾丸间质细胞瘤发病率低，临床易误诊，确诊需依赖病理组织学检查，尤其对年轻未育者，术中快速冰冻检查有助于手术范围的选择。
Objective To discuss the clinicopathological characteristics of Leydig cell tumor of the testis. Methods Two cases of Leydig cell tumor of the testis, both aged 27 year-old. One patient, with the major complaint of swelling and pain in left testis for about four months, and the other, intertility after three years of marriage with a palpable mass in right testis for about one month, were admitted to our hospital. B-ultrasound revealed hyperechomass （1.0 cm × 1.3 cm and 0.8 cm×0.6 cm respectively） with clear boundary in the testis. Then, tumor enucleation was conducted in two patients. Results Leydig cell tumor of the testis was diagnosed by frozen section analysis during the operation. Microscopically, the neoplasm was composed of numerous medium-large sized cells of abundant esinophilic cytoplasm arranged in cords, nests or diffusion. The tumor cells were usually predominantly polygonal with clear cell margins. Immunohistochemically, tumor cells were stained positively for Vimentin, Calretinin and Inhibin. The pathological diagnosis for both patients was testicular Leydig cell tumor. No recurrence was observed in case 1 after 17 months of follow up. Neither case 2 with nine-month follow up. Conclusions The testicular Leydig cell tumor is rare and is easily to be misdiagnosed in clinic, the diagnosis can only be made by pathological examination. Frozen section analysis during the operation could be helpful in determining the choice of resection, especially for the young males with infertility.
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
2007年第2期135-138,共4页
Chinese Journal of Urology
关键词
睾丸
间质细胞瘤
Testis
Leydig cell tumor
