摘要
目的通过对消瘀散散剂、水提物与醇提物的体外透皮试验研究,比较不同提取工艺的经皮渗透特性,为剂型设计、药理、毒理试验及临床研究提供依据。方法以有效成分大黄素累积透皮百分率为测定指标,高效液相色谱法定量,用改良的Franz扩散池及离体兔皮进行体外透皮实验,比较该方散剂及水提物与醇提物透皮速度、透皮百分率与皮肤储量的差别。结果透皮速度由快至慢、皮肤储量由高到低,散剂、透皮总量由多至少依次为:醇提物>水提物>散剂。结论醇提物透皮速度最快,皮肤储量最多,透皮总量最多。
Objective To compare the transdermal characteristic in different extraction technology through the research of transdermal experiment on water and alcohol extracts of Xiaoyu powders and provide the base for drug form designs,pharmacology,toxicology experiment and clinical research.Method The accumulated penetration rate of emodin,a kind of effective component,was used as the determining indicator,the HPLC as quantifying,the improved Franz diffusion cells and vitro rabbit as the method to perform the transdermal test and compare the differences among the penetration rate,the percentage of transdermal and the reserves in skin bewteen water and alcohol extracts.Result The transdermal speed was from fast to slow,reserves of the skin from high to low.The total transdemal amount was ordering as follows： alcohol extractwater extractXiaoyu powder.Conclusion The alcohol extract is the fastest in speed,the most in the skin reserves and the most in the total amount.
出处
《湖南中医药大学学报》
CAS
2011年第9期41-45,共5页
Journal of Hunan University of Chinese Medicine
基金
深圳市福田区科技局资助项目(FTWS0842008)
