摘要
目的研究中国女性被动吸烟和NAT2基因多态性及其环境因素交互作用与乳腺癌易感性的关系。方法以病例对照研究的方法,150例乳腺癌患者和150例健康对照者采用聚合酶链反应-限制性片段长度多态性分析(PCR-RFLP),检测NAT2基因多态性,分析NAT2基因型的分布特征。结果 NAT2慢型者患乳腺癌的相对危险性是NAT2快型者的2.70倍,其95%C(I1.66～4.39),经统计学检验有统计学意义(P<0.05);被动吸烟的妇女患乳腺癌的相对危险性是不吸烟的1.88倍,其95%C(I1.18～2.98),经统计学检验有统计学意义(P<0.05);NAT2慢型同时被动吸烟者患乳腺癌的相对危险性是NAT2快型者且未暴露于被动吸烟者的4.37倍,其95%C(I2.29～8.35),经统计学检验有统计学意义(P<0.05)。结论 NAT2基因多态性和被动吸烟与乳腺癌的易感性有关,NAT2慢基因型且同时被动吸烟者增加患乳腺癌的危险性。
【Objective】 To evaluate the possible relationship between passive smoking and N-acetyltransferase 2 polymorphisms with breast cancer susceptibility among Chinese female.【Methods】 In the case-control study,NAT2 genotypes were determined by PCR-RFLP method in 150 patients with breast cancer and 150 healthy controls.【Results】 NAT2 slow acetylators was associated with an increased risk of breast cancer odds ratio（OR） 2.70,（95% confidence interval（95% CI） 1.66-4.39,P〈0.05,and for passive smoking（OR） 1.88,95% CI 1.18-2.98,P〈0.05,and for both of NAT2 slow acetylators and passive smoking（OR） 4.37,95% CI 2.29-8.35,P〈0.05.【Conclusions】 These findings suggest that NAT2 genetic polymorphism and passive smoking may be associated with breast cancer susceptibility.People with NAT2 slow genotype and passive smoking have higher breast cancer risk.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2011年第26期3271-3275,共5页
China Journal of Modern Medicine
基金
山东省自然科学基金资助项目(No:ZR2009CL005)
山东省高等学校科技计划项目资助项目(No:J09LF11
No:J08LG15)
关键词
乳腺肿瘤
病例对照
被动吸烟
NAT2
breast neoplasm
case-control study
passive smoking
N-acetyltransferase 2
