摘要
目的检测变态反应性鼻炎(allergie rhinitis,AR)患者外周血清中白细胞介素水平,探讨白细胞介素-4(IL-4)、肿瘤坏死因子-α(TNF-α)在AR发病中的作用。方法留取30例健康人58例AR患者外周血清,分别采用ELISA法,检测IL-4及TNF-α水平。结果 AR患者血清IL-4、TNF-α检测结果均明显增高,与正常对照组比较差异有统计学意义(P<0.01)。AR患者伴鼻息肉清中IL-4、TNF-α水平较无鼻息肉患者升高,两组间差异有统计学意义(P<0.01)。各组AR患者血清IL-4、TNF-α水平从1分→2分→3分级逐渐升高,均呈显著正相关(P均<0.01)。结论 IL-4和TNF-α在AR发病中可能起着重要作用,TNF-α也可能是IL-4升高的重要促进因子。
Objective To investigate the effects of TNF-alpha and IL-4 in the pathogenesis of allergic rhinitis.Methods Peripheral blood samples were obtained from 30 healthy volunteers and 58 patients with allergic rhinitis.The expression of IL-4 and TNF-alpha was detected using ELISA method.Results The expression of IL-4 and TNF-alpha was significantly higher in patients with allergic rhinitis compared with control group and they were also significantly higher in allergic rhinitis with nasal polyps than without nasal polyps.The expression of IL-4 and TNF-alpha was gradually increased by 1point→2 point→3 point and the expression of IL-4 was significantly positively correlated with TNF-alpha.Concclusion IL-4 and TNF-alpha play important roles in the pathogenesis of allergic rhinitis and TNF-alpha possibily enhance the expression of IL-4.
出处
《中国误诊学杂志》
CAS
2011年第28期6808-6809,共2页
Chinese Journal of Misdiagnostics
