摘要
用药动学-约效学结合模型,对ⅳ乙酰普鲁卡因胺(NAPA)后,进行了药代动力学和药效动力学分析。兔体内NAPA ⅳ后与静脉推注后的药动学参数基本一致;但效应按QT_C延长作为指标,其药效动力学的个别参数有显著性差异。输注后,NAPA的E_(max),K_(eo),S和EC_(50)分别为120±13.2ms,0.0182±0.007min^(-1),2.26±0.93和6.31±0.71μg/ml;推注后,分别为53.6±2.5ms,0.061±0.017min^(-1),2.19±0.39和6.21±1.74μg/ml。
The pharmacokinetic and pharmacodynamic profiles of N-acetyl procainamide were analyzed by integrated PK-PD model following intravenous infusion to rabbits. No significant differences between the PK parameters estimated from iv administration and intravenous infusion were found. However, two of the PD parameters were shown to be significantly different. The values of E_(max), K_(eo), S, EC_(50) were found to be 120±13.2 ms, 0.0182±0.007 min^(-1), 2.26±0.93, 6.31±0.71 μg/ml respectively following intravenous infusion; the corresponding values following iv administration were 53.6 ± 2.5 ms, 0.061±0.017min^(-1), 2.19±0.39, 6.21±1.74 μg/ml respectively.
出处
《药学学报》
CAS
CSCD
北大核心
1990年第8期578-583,共6页
Acta Pharmaceutica Sinica
基金
国家自然科学基金
关键词
NAPA
药代动力学
药效动力学
Pharmacokinetics
Pharmacodynamics
Combined pharmacokineticpharmacodynamic model
N-Acetylprocainamide
Compartment model.
