摘要
采用药动学－药效学结合模型，分析了锌在兔体内的处置和降低动脉血压的作用。ｉｖＺｎＳＯ１（Ｚｎ２＋，１ｍｇ·ｋｇ－１）后的血清Ｚｎ２＋浓度与时间曲线符合开放型二房室模型。药效－时间曲线符合Ｅｍａｘ模型。降低平均动脉压的作用滞后于血Ｚｎ２＋浓度的变化。其药效学参数为Ｋｅｏ＝０．１６１ｈ－１，Ｔ（ｋｅｏ）＝４．３０１ ｈ，Ｅｍａｘ＝１．６３７ｋＰａ，Ｃｅ（５０）＝９７．４０７μｍｏｌ·Ｌ－１。结果表明Ｚｎ２＋的作用部位可能在效应室。
The disposition and the reduction of mean arterial pressure of zinc were analyzed with combined pharmacokinetic and pharmacodynamic model in rabbits. After iv ZnSO4 (Zn￣(2+)1 mg·kg￣(-1)),the calcuations of pharmacokinetic parameters were based on two-compartment open model, The pharmacodynamic data were fitted to E_(max) model and the effect of arterial pressure reduction lagged behind the serum zinc concentration. The pharmacodynamic parameters were:K_(eo)=0.161 h￣1,4.301 h, E(max)=1.637 kPa, C_(e50)=97.407μmol·L￣1. The results indicate that the action site of zinc may be in the effect compartment.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1995年第2期143-146,共4页
Chinese Pharmacological Bulletin
关键词
锌
药物动力学
药效学
血压
zinc
pharmacokinetics
pharmacodynamics
blood pressure
