摘要
肿瘤中淋巴管新生因子的过量表达会诱导更多的新生淋巴管而促进肿瘤的转移。淋巴管新生是影响肿瘤转移的一个重要因素。VEGF-A是VEGF家族中的一员,研究表明VEGF-A不仅能促进肿瘤淋巴管生成使肿瘤发生淋巴转移,且能够在原发肿瘤在发生转移之前,产生淋巴管生成因子使信号转导到前哨淋巴结。VEGF-A促进淋巴结转移已成为继血管转移研究后的又一热点,在此就VEGF-A与肿瘤淋巴管新生的研究近况予以综述。
The factors of lymphangiogenesis which is overexpressed in tumor can induce more new lymphatic to promote tumour metastasis.Lymphangiogenesis plays an important role in tumour metastasis.Vascular endothelial growth factor-A（VEGF-A） is a member of the VEGF family.Many studies indicated that VEGF-A not only promotes lymphangiogenesis,but also produces lymphatic endothelial growth factor transfer to the sentinel lymph node before primary cancer metastasis.In recent years,lymphatic metastasis become anthor hot research topic after blood vessels metastasis.Here is to review the progress of VEGF-A and tumor 1ymphangiogenesis.
出处
《医学综述》
2011年第19期2921-2923,共3页
Medical Recapitulate
基金
广西壮族自治区南溪山医院研究生科研创新基金(Y0902068)
