摘要
目的:制备一种酮洛芬缓释片剂。方法:采用挤出-滚圆法制备酮洛芬微丸,用Eudragit?RS 30D和Eudragit?RL30D包衣。再将包衣微丸与酮洛芬原药压片,最终制成酮洛芬缓释片。结果:体外释放度实验显示,制备的酮洛芬缓释片在2h内能释药30%,剩余70%药物在随后的10 h内缓慢释放。结论:用本方法制备酮洛芬缓释片,工艺简便,易于操作。
OBJECTIVE To prepare detoprofen sustained-release tablets. METHODS Extrusion-spheronization technique was introduced to prepare ketoprofen pellets and Eudragit RS 30D and Eudragit RL 30D were used as coating materials. Even mix the coated pellets with ketoprofen to prepare ketoprofen sustained release tablets. RESULTS The data obtained proved that the formulation was useful for a sustained-release of ketoprofen, due to the percentage released in two hours was 30% and in the later ten hours was 70%0. CONCLUSION The preparation technology is reliable and easy to operate.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2011年第20期1710-1713,共4页
Chinese Journal of Hospital Pharmacy
关键词
酮洛芬
挤出
滚圆法
丙烯酸树脂
微丸压片
体外释放度
ketoprofen
extrusion-spheronization technique
polyaerylic acid resin
peIlet tablets
in vitro releae
