摘要
目的：制备酮基布洛芬凝胶贴片，并考察体外经皮渗透性。方法：以聚乙烯醇（ＰＶＡ）和甘油为载体，以尿素为促进剂。结果：药物经皮渗透符合零级动力学过程，贴片中尿素含量超过１０％时，有显著的透皮促进作用。结论：贴片制剂稳定，符合临床用药要求。
OBJECTIVE: To study the prepartion of ketoprofen gel and its in vitro release. METHODS: PVA and glycerin was used as carriers.RESULTS: KFP was delivered at zero order.The higher the drug content,the faster the delivery speed.5% urea had no effect on KFP transdermal delivery.At a content of more than 10%,urea could significantly accelerate KFP transdermal delivery. CONCLUSION: Gel was stable and accorded the clinical demands.
出处
《药学实践杂志》
CAS
1999年第1期27-28,共2页
Journal of Pharmaceutical Practice
关键词
酮基布洛芬
聚乙烯醇
体外释药
透皮贴片
甘油
ketoprofen,polyvinyl alcohol,in vitro release,transdermal patch the clinical demands.
