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普伐他汀致横纹肌溶解症一例

One case of pravastatin induced rhabdomyolysis
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摘要 他汀类药物是3-羟基-3甲基戊二酰辅酶A(HMG-CoA)还原酶抑制药,通过抑制HMG-CoA还原酶,减少肝脏胆固醇的合成发挥作用,具有显著的调脂作用.此外,他汀类药物还具有稳定斑块、改善内皮功能、减少炎症、抑制血栓形成等多种非调脂作用[1].目前临床上他汀类药物被广泛应用于冠心病的二级预防,常见的不良反应为肝功异常和横纹肌溶解症.后者虽然罕见,但可致急性肾功能衰竭,甚至死亡,值得关注.本文报告1例与他汀类药物相关的急性横纹肌溶解症.
出处 《中国心血管病研究》 CAS 2011年第10期792-793,共2页 Chinese Journal of Cardiovascular Research
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