摘要
目的探讨首发精神分裂症患者认知功能的损害情况,为精神分裂症的进一步研究提供依据。方法采用威斯康星卡片测试(WCST)、连线测试(TMT)、数字广度、数字-符号测试对40例首发精神分裂症患者与40例健康对照者进行研究,对其认知功能进行t检验分析。结果两组WCST评分显示:研究组WCST的总应答数(Ra)、持续错误数(Rpe)、持续性应答(Rp)均高于健康对照组,完成分类数(Cc)、正确应答数(Rc)低于健康对照组,差异有统计学意义(t值分别为-3.89,-6.62,-7.13,-7.26,-7.04,P<0.01)。研究组TMT-A用时明显大于健康对照组(P<0.01),TMT-B错误数显著多于健康对照组(P<0.01)。研究组与健康对照组在韦氏成人智力量表(WAIS)中数字广度、数字-符号测试差异有统计学意义(P<0.01)。结论首发精神分裂症患者在抽象概括能力、概念形成、认知转移能力、记忆、注意能力及速度方面有明显损害,而在执行能力、选择性记忆方面损害尚不显著。对于精神分裂症患者可以辅助进行心理治疗。
Objective To investigate the cognitive function damage in patients with first-episode schizophrenia,and provide the basis for further study of mental health.Methods 40 cases of first-episode schizophrenia and 40 normal controls were tested with Wisconsin Card Test（WCST）,Trail making test（TMT）,Digit span test（clockwise and anticlockwise） and Digital symbol test.The cognitive function was analyzed by t test.Results Compared with the normal group,the research group got significantly higher scores in total responses（Ra）,perseverative errors（Rpe） and perseverative responses（Rp）,while lower scores in categories completed（Cc） and correct responses（Rc）.（t=-3.89,-6.62,-7.13,-7.26,-7.04,all P0.01）.And the research group took more time in TMT-A than the normal group,also it made more mistakes in TMT-B（P0.01）,and there′s significant difference in digit span and digit symbol test in WAIS（P0.01）.Conclusion The study suggests that the first-episode schizophrenia is significantly damaged in Abstraction capabilities,conception formatting,cognitive transfer,memory,attention and speed,but there′s no significant differences in implementation capacity,selective memory.So the treatment of schizophrenia can be combined with the cognitive characteristics of psychological cure.
出处
《检验医学与临床》
CAS
2011年第19期2315-2316,共2页
Laboratory Medicine and Clinic
关键词
精神分裂症
首发
认知功能损害
schizophrenia
first-episode
cognitive function damage
