摘要
目的:研究注射用利培酮微球对精神分裂症患者认知功能的改善作用。方法:60名受试者随机分为两组,分别给予注射用利培酮微球和氟哌啶醇片治疗。分别在基线期、第4,8,12和16周进行PANSS、认知功能测查,并分析结果。结果:注射用利培酮微球组在威斯康星实验完成分类数从第4周起各时点较基线有显著性差异(P<0.05),而氟哌啶醇各时点数据与基线无显著差异,但组间比较无显著差异(P>0.05)。注射用利培酮微球组在持续性操作测验的反应时间,数字广度评分上的表现优于氟哌啶醇组(P<0.05),且注射用利培酮微球组持续性操作测验的反应时间从第4周起,数字广度上第8,16周与基线比较有显著性差异(P<0.05)。结论:注射用利培酮微球对执行功能、注意及工作记忆有改善作用,且这种改善作用优于氟哌啶醇。
Objective：To investigate the improving efficacy of risperidone long-acting injection on cognitive functions in patients with schizophrenia.Methods：Patients were randomized to either risperidone long-acting injection（n=28） or haloperidol（n=32） treatment group.Their clinical characters and cognition abilities were re-examined at baseline,and 4,8,12,and 16 weeks after the treatments.Results：Compared with baseline,risperidone long-acting injection significantly improved sorting numbers of WCST from 4th week（P〈0.05）,but haloperidol had no this effect.The difference between two groups was not significant（P〉0.05）.Compared with baseline,risperidone long-acting significantly improved reaction time of Continuous Performance Test（CPT） from 4th week（P〈0.05）,and significantly improved performance of Digit Span Test at 8th and 16th week（P〈0.05）;however,haloperidol had no these effects.The significant difference between two groups was demonstrated（P〈0.05）.Conclusion：Long term treatment of risperidone long-acting injection can improve executive function,attention,working memory,and performed better than haloperidol.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2010年第22期2081-2084,共4页
Chinese Journal of New Drugs
