摘要
目的为足癣治疗提供较理想的方案。方法盐酸特比萘芬250 mg,口服1次/d;1%联苯苄唑乳膏,外用1次/d。250例足癣患者随机入组。A组口服1周加外用1周,B组口服1周加外用2周,C组口服2周加外用1周,D组口服2周加外用2周,E组单独外用4周。在治疗结束时、治疗结束后4周、24周、40周、56周、72周时对各组的疗效、复发率进行评价。结果在停药后第24周时,A、B、C、D组与E组疗效比较差异有统计学意义。在停药后第40周、56周、72周时,D组与A、B组疗效比较差异也出现统计学意义。在停药后24周、40周时,A、B、C、D组真菌学疗效与E组比较差异有统计学意义。在停药56周、72周时,D组与A、B组真菌学疗效比较差异也出现统计学意义。在停药40周时,A、B、C、D组与E组复发率比较差异有统计学意义。在停药56周、72周时,D组与A、B组复发率比较差异也出现统计学意义。结论口服特比萘芬2周联合外用1%联苯苄唑乳膏2周治疗足癣的有效率和真菌学疗效最高,复发率最低。
Objective To find the best schedule for tinea pedis treatment.Methods A total of 250 patients with tinea pedis were divided into five groups： group A（oral terbinafine combined with 1% topical bifonazole cream for 1 week）,group B（oral terbinafine for 1 week combined with 1% topical bifonazole cream for 2 weeks）,group C（oral terbinafine for 2 weeks combined with 1% topical bifonazole cream for 1 week）,group D（oral terbinafine combined with 1% topical bifonazole cream for 2 weeks）,and group E（only 1% topical bifonazole cream for 4 weeks）.Efficacy and relapse rates were analysed at the end point,week 4,24,40,56 and week 72.Results By the end of week 24,40,56 and week 72,clinical effective rate in group A,B,C and D showed statistical difference with that in group E,while group D showed statistical difference with group A and B by the end of week 40,56 and week 72.At week 24,40,56 and week 72,microbiological cure rate in group A,B,C and D showed statistical difference with that in group E,while group D showed statistical difference with group A and B at week 56 and 72.At week 40,relapse rates in group A,B,C and D were statistically different from that in group E,while at week 56 and 72,group D showed statistical difference with group A and B.Conclusions Two-week treatment with oral terbinafine and 1% topical bifonazole cream has the best therapeutic effect and lowest relapse rate.
出处
《中国真菌学杂志》
2011年第4期220-224,共5页
Chinese Journal of Mycology
关键词
足癣
特比萘芬
联苯苄唑乳膏
疗效
复发率
tinea pedis
terbinafine
bifonazole cream
treatment
relapse rate
