摘要
目的:探讨晚期卵巢癌进行初次肿瘤细胞减灭术术后发生深静脉血栓(DVT)的影响因素。方法:收集2000年1月至2010年10月间FIGOⅢ～Ⅳ期卵巢上皮性癌住院患者81例,以术后是否发生DVT分为血栓组和非血栓组,将影响因素分为术前临床参数(年龄、体重指数、合并心血管疾病、血栓史、术前血小板计数、术前血清纤维蛋白原、术前血清CA125)、手术相关因素(手术时间、是否满意减瘤、出血量、输血量)和术后参数(卧床天数、是否使用抗凝药物)进行分析。结果:全组术后发生DVT共16例,发生率为19.75%。血栓组与非血栓组比较,经单因素分析年龄、体重指数(BMI)、合并心血管疾病、血栓史、术前纤维蛋白原、输血量、卧床天数(P<0.05)是术后DVT发生的高危因素,经Logistic回归多因素分析BMI、术前纤维蛋白原、卧床天数(P<0.05,OR值分别为1.790、2.750、3.090)是术后DVT发生的独立影响因素结论:有高危因素的晚期卵巢癌患者术后容易发生DVT,对于肥胖、术前高纤维蛋白原、有卧床时间长倾向的患者,应特别注意预防术后发生DVT。
Objective： To explore the influencing factors of deep venous thrombosis （ DVT ） in patients with advanced eplthehal ovarian cancer （ AdEOC ） after undergoing primary cytoreductive surgery. Methods： Data of 81 patients with AdEOC who underwent primary cytoreduction surgery in the First Affiliated Hospital of Fujian Medical University from January 2000 to October 2010 were retrospectively analyzed. The patients were divided into Group A with DVT and Group B without DVT. The influencing factors were analyzed by univariate and multivariate methods, including preoperative clinical parameters, i.e., age, body mass index （ BMI ）, a complicated cardiovascular disease, a history of thromboembolism, preoperative serum fibrinogen, blood platelet and serum CA125; surgery-related parameters, i.e., time of surgery, optimal debulking and volume of blood loss and transfusion; and postoperative parameters, i.e., days of bed rest and use ot antl-coagumuon drugs. Results： In our study, the occurrence rate of postoperative DVT was 19.75%. In a comparison between Groups A and B, the univariate analysis indicated that age, BMI, a complication of cardiovascular disease, a history of previous thromboembolism, preoperative serum fibrinogen, transfusion volume, and days of bed rest were the postoperative high-risk factors of DVT （ P 〈 0.05 ）. The multivariate logistic regression analysis showed that BMI, preoperative serum fibrinogen, and postoperative days of bed rest were the independent influencing factors for the occurrence of DVT after surgery （ P 〈 0.05 ）. The risk ratios were 1.790, 2.750 and 3.090, respectively. Conclusion： DVT frequently occurs in AdEOC patients with high-risk factors after cytoreductive surgery. As for prevention of postoperative DVT, more attention should be paid to patients who are obese, with high preoperative serum fibrinogen, and with tendency for longer bed-rest.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2011年第17期1039-1042,共4页
Chinese Journal of Clinical Oncology
关键词
卵巢上皮性癌
深静脉血栓
肿瘤细胞减灭术
Epithelial ovarian cancer, Deep venous thrombosis （DVT）, Cytoreductive surgery
