摘要
目的观察大剂量氨溴索对术后急性呼吸衰竭的治疗作用。方法选择术后急性呼吸衰竭患者40例,随机分为试验组和对照组,每组20例。2组患者在常规机械通气、抗感染及营养支持等综合治疗的基础上,试验组每天给予氨溴索10mg/kg持续静脉微量泵注射,对照组每天给予等容积生理盐水,均连续7d。比较2组治疗前和治疗后2、5、7d的动脉血气及ICU治疗时间。结果 2组患者治疗后PaO2和PaO2/FiO2水平均有不同程度升高(P<0.05),且试验组治疗后2、5、7dPaO2和PaO2/FiO2水平均显著高于对照组(P<0.05)。试验组患者ICU住院时间为(8.2±5.8)d明显短于对照组的(10.4±6.6)d,差异有统计学意义(P<0.05)。结论大剂量氨溴索能促进术后急性呼吸衰竭患者氧合状况的改善,缩短ICU治疗时间。
Objective To investigate the effect of high dose ambroxol on patient with acute respiratory failure after surgery.Methods Forty cases patients with postoperative acute respiratory failurewere were divided randomly into experimental group and control group,each of 20 cases.On the base of treatment,experimental group were given ambroxol 10mg/kg per day by continuous intravenous micro pump injection,control group were given saline every day.Compared before treatment and after treatment 2,5,7d of arterial blood gas and ICU treatment time of 2 groups.Results After treatment PaO2 and PaO2/FiO2 levels of 2 groups were increased（P0.05）,and after treatment 2,5,7d the level of PaO2 and PaO2/FiO2 of experimental group were significantly higher than those of control group（P0.05）.ICU length of stay time of experimental group[（8.2±5.8）d] was significantly shorter than that of control group[（10.4±6.6）d],the difference was statistically significant（P0.05）.Conclusion High dose of ambroxol can improve blood gas exchange and decrease the length of ICU stay in the patient with postoperative acute respiratory failure.
出处
《临床合理用药杂志》
2011年第11期11-12,共2页
Chinese Journal of Clinical Rational Drug Use
关键词
氨溴索
术后
呼吸衰竭
急性
Ambroxol
Postoperative
Respiratory failure
acute
