摘要
目的应用Meta分析方法对国内外已发表的有关泮托拉唑预防重症颅脑外伤并发应激性上消化道出血的疗效进行综合评价。方法对符合纳入标准的15篇文献用Re-view manager 5软件包进行Meta分析,计算比值比(OR)、95%可信区间(95%CI),并做出几何漏斗图和森林图。结果纳入总样本量为2 203例,其中病例组为902例,对照组为1 311例;Meta分析合并OR=2.989,5%CI(2.02,4.39)。几何的漏斗图形基本对称,但双侧底部出现缺失,经敏感性分析显示,发表偏倚对研究结果影响较小。结论证明了泮托拉唑能安全有效地预防和减少颅脑外伤重症患者应激性溃疡的发生。
Objective It is to evaluate the preventing effect of pantoprazole on severe craniocerebral injury complicating with stress upper gastrointestinal bleeding in the published studies in all the world with Meta-analysis. Methods Fifteen references consistent with inclusion criteria were accepted Meta analysis by reviewing manager 5, calculating the odds ratio and 95% confidence interval,then drawing funnei plot and forest plots. Results The total sample size were 2 203, in which cases and controls were 902 and 1 311 respectively. Meta analysis combined with OR = 2.98, and 95% confidence interval （2.02, 4.39）. The graphical funnel plot appearing symmetrical, the missing point appear on both sides of the bottom. But the analyzing by sensitivity analysis showed that the results are little effected by publication bias. Conclusion The results of our Meta analysis show that pantoprazole is a safe and effective drug for preventing stress upper gastrointestinal bleeding in severe craniocerebral injury patients.
出处
《现代中西医结合杂志》
CAS
2011年第28期3526-3529,共4页
Modern Journal of Integrated Traditional Chinese and Western Medicine
关键词
泮托拉唑
上消化道出血
颅脑外伤
META分析
Pantoprazole
upper gastrointestinal bleeding
craniocerebral injury
Meta - analysis
