摘要
目的研究乳酸杆菌阴道胶囊治疗低危的妊娠期细菌性阴道病(BV)的转阴率及其与不良妊娠结局间的关系,评估双疗程方案对治疗后持续BV阳性患者的意义。方法选用唾液酸酶法对孕16～20周的低危患者进行BV筛查,追踪比较乳酸杆菌阴道胶囊单疗程治疗组、双疗程组和对照组3组病人治疗后1周及孕晚期的转阴率及妊娠结局。结果 BV总检出率为17.6%。在治疗后1周及孕晚期,对照组的转阴率分别为1.2%和62.3%,两治疗组的BV转阴率均高于80%,对照组与两治疗组间的差异有统计学意义(P<0.01)。对照组较两治疗组的胎膜早破发生率高、分娩孕周短、产后出血量多、新生儿出生体重轻、产妇产后第1天的体温高。对于持续性BV阳性的病人,双疗程组与单疗程组在BV转阴率、不良妊娠结局间的差异无统计学意义。结论低危妊娠期BV患者予乳酸杆菌阴道胶囊治疗能使BV有效转阴,并可改善妊娠结局。对于治疗后持续性BV阳性的病人,暂无证据支持予第二疗程治疗。
Objective To examine the effect of lactobacillus preparation on bacterial vaginosis（BV） in low-risk pregnant women and to evaluate the value of double courses for the patients with durative positive result.Methods Pregnant women at 16-20 gestational weeks with no history of premature labor or premature rupture of fetal membranes were screened for BV by sialidase method and randomly allocated into control group,one-course group and two-course group.Patients who had durative BV positive result received the second course of lactobacillus preparation in two-course group.The pregnancy outcome of these three groups was followed-up.Results The prevalence of BV was 17.6%.After 1 week of treatment and late pregnance,the sero conversion rates of the control groups were 1.2% and 62.3%,respectively,while the sero conversion rates of the 2 treament groups were both over 80%,showing a significant difference （P0.01）.When compared with the 2 treatment groups,the control groups showed a higher rate of remature rupture of fetal membrane,shorter gestation,more bleeding after delivery,lighter weight of the new born baby,and high temperature at the afirst day after delivery.For the continuous BV positive patients,the one-course intervention and two-course intervention showed no significant difference in BV sero conversion and adverse pregnancy outcome.Conclusion For the low risk pregnant women with BV,lactobacillus vaginal capsules treatment can effectively sero convert and improve the pregnancy outcome.However,for the patient continuous BV positive after treatment,there is no evidence to show that a second treatment is effective.
出处
《热带医学杂志》
CAS
2011年第8期920-923,共4页
Journal of Tropical Medicine
基金
广州市卫生局一般引导项目(2009-YB-187)
