摘要
目前大量的研究证明,HBV感染是引起原发性肝癌的主要原因。核因子κB(NFκ-B)的发现,在炎症和肿瘤之间搭起了一座桥梁。HBV通过自身直接或者间接引起NFκ-B的激活,NFκ-B又作用于致癌因子,从而引发肿瘤。但这种相互作用不是单向的,而是级联放大的负反馈。NFκ-B不仅参与肝癌的发生、发展,还与化疗药物耐药有关,NFκ-B在HBV感染引起的肝癌中的作用至关重要。
It has been proved that hepatitis B virus infection is the main factor causing hcpatocellular carcinoma（HCC）. The discovery of NF-KB set up a bridge between inflammation and tumor. NF-KB is activated by hepatitis B virus directly or indirectly, which then results in cancer by acting on carcinogcns. The interaction is a negative feedback which is cascade amplified rather than unidirectional. Not only did NF-kB take part in the development in cancer, bat also primary drug resistance. NF-kB plays a rather important role in HBV infection related hepatocellular carcinoma. The HBV-NF-kB-HCC clues will be reviewed in this article.
出处
《医学综述》
2011年第17期2614-2617,共4页
Medical Recapitulate
关键词
核因子ΚB
乙型肝炎病毒
肝细胞肝癌
Nuclear factor-kB
Hepatitis B virus
Hepatocellular carcinoma
