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乙型肝炎病毒再激活与T细胞亚群的相关性研究 被引量:3

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摘要 目的探讨肺结核合并乙型肝炎病毒感染患者抗结核治疗后乙型肝炎病毒再激活与T细胞亚群的关系。方法96例肺结核合并乙型肝炎病毒感染患者人院后常规检测CD3、CIM、CD8。按照CD3及CD4从低到高排序,1~48为观察组,49~96为对照组。抗结核治疗3个月后观察两组患者HBV再激活发生例数及发生率。对所有发生HBV再激活患者再次检测CD3、CIM、CD8,观察HBV再激活前后CD3、CD4、CD8的变化。结果观察组48例患者中发生HBV再激活者26例,发生率为54.17%(26/48)。对照组48例患者中发生HBV再激活者16例,发生率为33.33(26/48)。两组发生率比较差异有统计学意义(P〈0.05)。另外,HBV再激活后CD3、CD4、CD4/CD8进一步下降,CD8继续升高。结论肺结核合并乙型肝炎患者在抗结核治疗后,免疫功能相对低下者更易发生乙肝病毒再激活。乙肝病毒再激活后,机体的免疫功能进一步下降。
出处 《中国医学创新》 CAS 2011年第26期24-25,共2页 Medical Innovation of China
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