摘要
目的探讨帕金森病(PD)患者血小板5-羟色胺(5-HT)水平的改变及其与抑郁、认知功能障碍的关系。方法采用高效液相色谱法检测54例PD患者和54名健康中老年人(正常对照组)的血小板5-HT水平。采用汉密尔顿抑郁(HAMD)量表和简易精神状态检查(MMSE)量表对PD患者进行评分,并对血小板5-HT水平与HAMD和MMSE量表评分进行相关性分析。结果 PD患者血小板5-HT水平比正常对照组显著降低(P<0.05),并且PD伴抑郁、认知功能障碍患者的血小板5-HT水平分别显著低于PD无抑郁及无认知功能障碍患者(均P<0.05)。PD患者血小板5-HT水平与HAMD量表评分呈负相关(r=-0.3310,P<0.05),与MMSE量表评分呈正相关(r=0.5415,P<0.05);PD伴抑郁患者的MMSE量表评分显著低于无抑郁患者(P<0.05)。结论 PD患者的血小板5-HT水平明显降低,并且PD伴抑郁和认知功能障碍患者的血小板5-HT水平降低更明显。
Objective To investigate the change of the level of platelet 5-hydroxytryptamine （HT） and its correlation with depression and cognitive dysfunction in patients with Parkinson disease （PD）. Methods The levels of platelet 5-HT was measured in 54 PD patients and 54 healthy aged and elderly people （ normal control group） by high performance liquid chromatography. PD patients were measured by Hamilton depression rating scale （HAMD） and Mini-mental state examination （MMSE） scale. The correlation analyed between the level of platelet 5-HT and HAMD, MMSE. Results The level of platelet 5-HT in PD group was significantly lower than that in normal control group（P 〈 0.05 ）, and the level of 5-HT in PD patients with depression or cognitive dysfunction was significantly lower than that in PD patients without depression or cognitive dysfunction（ all P 〈 0.05 ）. The level of platelet 5-HT was negative correlation with HAMD score（ r = -0. 3310 ,P 〈 0.05 ） , and positive correlation with MMSE score（ r = 0. 5415 ,P 〈0. 05 ）. The MMSE score in PD patients with depression was significantly lower than that in PD patients without depression（ P 〈0. 05 ）. Conclusion The level of platelet 5-HT in PD patient is decreased significantly, which even lower in PD patients with depression and cognitive dysfunction.
出处
《临床神经病学杂志》
CAS
北大核心
2011年第4期264-266,共3页
Journal of Clinical Neurology
关键词
帕金森病
5-羟色胺
血小板
抑郁
认知功能障碍
Parkinson disease
5-hydroxytryptamine
platelet
depression
cognitive dysfunction
