摘要
目的通过研究基于Micro CT数据的大鼠股骨皮质骨材料性质与力学性能的关系,探讨振动在对抗骨量丢失过程中的生物力学评价方法。方法 Wistar大鼠35只,尾部悬吊建立废用性骨质疏松模型,随机分为间歇振动1、3、5、7 d和持续振动组。实施35 Hz、0.3 g的机械振动,8周后处死,取其左侧股骨行Micro CT扫描,建立皮质骨三维有限元模型,计算获得其表观和组织水平的力学参数。通过主元素分析法从材料分布、间歇振动天数、体积分数中提取主元素。结果提取出了能够全面反映振动下皮质骨材料性质的3个主元素,并建立起主元素与表观和细观力学参数之间的回归方程。影响皮质骨力学性能的主要因素为材料分布,体积分数与间歇振动天数的影响次之。结论皮质骨的材料性质能够反映其力学性能的变化,通过材料性质与力学性能的关系可以评估骨强度,为骨质疏松的振动防治及其康复过程的评价提供理论依据。
Objective To explore biomechanical assessment for the effects on vibration against bone loss by investigating the relationship between material distribution and mechanical properties of rat femur cortical bone based on Micro CT.Methods 35 rats were randomly divided into intermittent vibration groups with the interval of 1,3,5,7 days,and continuous vibration group,respectively.Tail suspended model of disuse osteoporosis was set up.All rats were loaded with mechanical vibration of 35 Hz and 0.3 g,and killed after 8 weeks.Micro CT scanning of the left femur of each rat was performed.Three-dimensional finite element model of the cortical bone was established to calculate the apparent and tissue-level mechanical parameters.Principal components（PCs） were extracted from material distribution,intermittent days and volume fraction by principal components analysis（PCA）.Results The PCA revealed the three independent components that could fully explaine the variability of cortical bone characteristics under vibration.The linear regression equations were also created between the material property and the apparent and tissue-level mechanical properties,respectively.Mechanical properties of the cortical bone were influenced by material distribution mostly,and the volume fraction and intermittent days were next in importance.Conclusions The cortical bone material distribution can reflect changes in its mechanical properties,and the bone strength could be assessed by establishing the linear relationship,which could provide a theoretical basis for osteoporosis prevention and treatment as well as the assessment on its rehabilitation process.
出处
《医用生物力学》
EI
CAS
CSCD
2011年第4期315-320,共6页
Journal of Medical Biomechanics
基金
国家自然科学基金资助项目(10972090
10832012
10872078)
吉林大学科学前沿与交叉学科创新项目(200903169)
关键词
CT扫描
振动
皮质骨
材料分布
力学性能
有限元分析
康复
CT scans
Vibration
Cortical bone
Material distribution
Mechanical properties
Finite element analysis
Rehabilitation
