期刊文献+

老年脑梗死患者高同型半胱氨酸血症与动脉粥样硬化斑块的相关性分析 被引量:5

The correlation ship between the hyperhomocysteimia and atheroma in the cerebral infarction patients
下载PDF
导出
摘要 目的探讨高同型半胱氨酸(Hcy)血症与动脉粥样硬化的相关性。方法测定脑梗死组和健康对照组的血清Hcy,利用彩色多普勒超声检查各组颈动脉粥样硬化情况,对比老年脑梗死患者和正常人的血清Hcy水平。结果脑梗死组血清Hcy水平为(19.63±6.74)μmol/L,而健康对照组血清Hcy水平为(13.76±3.95)μmol/L,两组比较差异有统计学意义(P<0.05)。血清Hcy水平与IMT增厚有显著相关性(P=0.004)。结论高Hcy血症是动脉粥样硬化形成的重要原因,是脑梗死发病的独立危险因素。 Objective To investigate the association between the Hcy and atheroma progression in aged patients with cerebral infarction.Methods 60 consecutive hospitalized cerebral infarction patients whose carotid intima-media thickness(IMT)more than 1.2mm and 42 healthy controls were chosen in our study.Serum Hcy level was determined,and carotid atheroma was detected by color doppler ultrasound.Results The serum Hcy of the patient was higher significantly than that of the normal controls.The serum Hcy level was significantly associated with atheroma(P=0.004).Conclusion The high serum Hcy level is an independent risk factor for cerebral infarction.
出处 《中国临床保健杂志》 CAS 2011年第4期368-369,I0001,共3页 Chinese Journal of Clinical Healthcare
关键词 脑梗死 半胱氨酸 动脉粥样硬化 危险因素 Brain infarction Cysteine Atherosclerosis Risk factors
  • 相关文献

参考文献11

二级参考文献18

共引文献37

同被引文献55

  • 1王杰,张志军.联合应用叶酸和甲钴胺对脑梗塞患者高同型半胱氨酸血症的影响[J].陕西医学杂志,2004,33(12):1118-1119. 被引量:6
  • 2Kaul S,Zadeh AA,Shah PK.Homocysteine hypothesis for atherothrombotic cardiovascular disease:not validated[J].J Am Coll Cardiol,2006,48(5):914-923. 被引量:1
  • 3Ueland PM,Refsum H,Stabler SP,et al.Total homocysteine in plasma of serum:methods and clinical applications[J].Clin Chem,1993,39(9):1764-1769. 被引量:1
  • 4Sen U,Mishra PK,Tyagi N,et al.Homocysteine to hydrogen sulfide or hypertension[J].Cell Biochem Biophys,2010,57(2/3):49-58. 被引量:1
  • 5Dayal S,Aming E,Bottiglieri T,et al.Cerebral vascular dysfunction mediated by superoxide in hyperhomocysteinemic mice[J].Stroke,2004,35(8):1957-1962. 被引量:1
  • 6Austin RC,Lentz RS,Wershuck GH.Role of hyperhomocysteinemia in endothelial dysfunction and atherothrombotic disease[J].Cell Death Differ,2004,11:S56-S64. 被引量:1
  • 7管翠玲,荣海钦.高尿酸血症与心脑血管疾病[J].医学综述,2007,13(15):1149-1151. 被引量:5
  • 8Sen S,Reddy PL,Grewal RP,et al.Hyperhomocysteinemia is associated with aortic atheroma progression in stroke/TIA pa- tients[J].Front Neurol,2010,1:131. 被引量:1
  • 9Fassbender K,O Mielke,M Hennerici,et al.,Plasma homo- cyst(e)ine concentrations in cerebrovascular disease[J].Stroke,1999,30(10):2 244-2245. 被引量:1
  • 10Malinow MR,Bostom AG,Krauss RM.Homocysteine*diet,and cardiovascular diseases; a statement for healthcare profes- sionals from the Nutrition Committee* American Heart Associ- ation[J].Circulation,1999,99(1):178-182. 被引量:1

引证文献5

二级引证文献34

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部