摘要
目的:探讨急性脑梗死患者外周血炎症指标hs-CRP、CD3+/HLA-DR+和中性粒细胞CD64指数与颈动脉粥样硬化程度的关系。方法:100例急性脑梗死患者(梗死组)经颈动脉彩色多谱勒超声证实为颈动脉粥样硬化,按病变程度分为颈动脉内膜增厚组(A亚组)20例、颈动脉斑块组(B亚组)56例、颈动脉狭窄组(C亚组)24例,选择50例健康体检者为对照组。采用免疫透射比浊法及流式细胞学检测各组患者外周血hs-CRP、CD3+/HLA-DR+和中性粒细胞CD64指数水平,并分析这些指标与颈动脉粥样硬化的关系。结果:梗死组hs-CRP、CD3+/HLA-DR+水平均明显高于对照组(P均<0.01);且hs-CRP与CD3+/HLA-DR+水平呈正相关(Pearsonr=0.408,P<0.01)。梗死组中性粒细胞CD64指数与对照组比较差异无统计学意义(P>0.05)。C亚组的hs-CRP、CD3+/HLA-DR+水平高于A亚组、B亚组(P均<0.01),颈动脉粥样硬化程度与hs-CRP、CD3+/HLA-DR+呈正相关(Spearmanrs=0.322,P<0.01;Spearmanrs=0.387,P<0.01)。而C亚组的中性粒细胞CD64指数与A亚组、B亚组比较差异无统计学意义。结论:急性脑梗死患者外周血hsCRP、CD3+/HLA-DR+可在一定程度上反映该患者的颈动脉粥样硬化程度。
Objective：To explore the relationship of inflammatory indexes including hs-CRP,CD3＋/HLA-DR＋ and neutrophil CD64 in peripheral blood and carotid atherosclerosis in acute cerebral infarction patients. Methods ： 100 patients with acute cerebral infarction （infarction group） who were confirmed to have carotid atherosclerosis by color ultrasound examination,were divided into carotid intima thickening group （n=20）,carotid plaque group （n=56） and carotid stenosis group （n=24） according to the degree of lesion. 50 healthy controls were recruited as the control group. The levels of hs-CRP, CD3^＋/HLA-DR^＋ and neutrophil CD64 index in all groups were detected by immune turbidimetry and flow cytometry, respectively, and the correlation between the inflammation index and the degree of CAS was analyzed. Result ： The levels of hs-CRP and CD3^＋/HLA-DR^＋ in infarction group significantly increased comparing with the control group （ P 〈 0.01 ）. In the infarction group, the level of hs-CRP had a positive correlation with CD3^＋/HLA-DR^＋ （ Pearson r=0. 408, P 〈 0.01 ）. The neutrophil CD64 indices in infarction group were not significantly higher than that in the control group （ P 〉 0.05 ）. The levels of hs-CRP and CD3^＋/HLA-DR^＋ in carotid stenosis group were significantly higher than those in carotid intima thickening group and carotid plaque group . The levels of hs-CRP and CD3 ＋/HLA-DR ~ in carotid plaque group were significantly higher than those in carotid intima thickening group. The severity of CAS had significant correlation with the levels of hs-CRP and CD3^＋/HLA-DR ＋ （ Spearman rs = 0. 322, P 〈 0.01 ;Spearman rs=0. 387, P 〈 0.01）. There was no difference among carotid intima thickening group, carotid plaque group and carotid stenosis group. Conclusion ： The levels of hs-CRP and CD3^＋/HLA-DR^＋ in the peripheral blood of patients with acute cerebral infarction may reflect the severity of CAS, except neutrophil CD64.
出处
《海南医学院学报》
CAS
2009年第12期1526-1529,共4页
Journal of Hainan Medical University
基金
深圳市科技计划项目(NO.200903065)~~
