摘要
目的观察长春西汀加银杏叶提取物(舒血宁)治疗椎-基底动脉供血不足(VBI)的临床疗效。方法将144例VB I患者随机分为对照组、长春西汀治疗组、舒血宁治疗组和长春西汀加舒血宁联合治疗组。对照组采用西医常规治疗;长春西汀治疗组使用长春西汀注射液20 mg加入0.9%氯化钠注射液100 m l中静脉滴注;舒血宁治疗组使用舒血宁注射液20 m l加入0.9%氯化钠注射液100 m l中静脉滴注;联合治疗组两药联用,用法同上;均为每日1次。治疗2周后比较4组的临床疗效、椎-基底动脉平均血流速及血液流变学指标变化。结果 (1)总有效率联合治疗组(94.4%)、长春西汀组(77.8%)和舒血宁组(75%)均高于对照组(63.9%)(P<0.05),且联合治疗组高于长春西汀组和舒血宁组(P<0.05);(2)4组患者治疗后椎—基底动脉平均血流速及血液流变学指标均较治疗前改善(P<0.05);(3)治疗后,联合治疗组患者椎-基底动脉平均血流速及血液流变学指标较长春西汀组和舒血宁组改善明显(P<0.05)。结论长春西汀和银杏叶提取物能有效治疗VBI,且两者联合应用较单一用药效果更好。
Objective To observe the curative effect of vinpocetine and Shu-Xue-Nin injection in treating vertebro-basilar artery insufficiency.Methods 144 cases with vertebro-basilar artery insufficiency were selected and divided into 4 groups randomly.Cases in the control group were given conventional therapy;Cases in the vinpocetine group were given intravenous drip infusion of 20mg vinpocetine combined with 250mL physiological saline,once daily.Cases in the Shu-Xue-Nin group were given intravenous drip infusion of 20mL Shu-Xue-Nin injection combined with 250mL physiological saline,once daily.Cases in the therapeutic alliance group were given intravenous drip infusion of vinpocetine and Shu-Xue-Nin injection once daily for 2 weeks.Results（1）The total effective rate of therapeutic alliance group（94.4%）,vinpocetine group（77.8%）and shu xue-nin group（75.0%）were higher than those in control group（63.9%）（P〈0.01）.The total effective rate of therapeutic alliance group were higher than those in vinpocetine group and in Shu-Xue-Nin group（P〈0.05）.（2）After the treatment,blood flow relocity of vertebrobasilar and hemorheology index of 4 groups improved more than those before the treatment（P〈0.05）.（3）After the treatment,blood flow relocity of vertebrobasilar and hemorheology index in therapeutic alliance group showed higher improvement than those in vinpocetine group and in Shu-Xue-Nin group（P〈0.05）.Conclusion Vinpocetine or Shu-Xue-Nin injection has a satisfactory effect on vertebro-basilar artery insufficiency.Combination treatment shows better effect than single one.
出处
《中国临床保健杂志》
CAS
2011年第4期364-367,共4页
Chinese Journal of Clinical Healthcare
