摘要
目的对肿瘤激素受体表达状态作为乳腺癌转移的一项预后指标进行评价。资料与方法根据转移方式对转移性乳腺癌患者进行分组,将57例雌激素受体(ER)和孕激素受体(PR)情况(ER+或ER-/PR+或PR-)已知的转移性乳腺癌患者纳入研究,并行脑MRI和全身骨核素扫描(ECT)等影像学检查。结果28例患者发生骨转移无脑转移,57%的患者ER+/PR+。7例患者有脑转移无骨转移,71%(5/7)的患者ER-/PR-。10例患者发生骨转移无脑转移且有其他部位的转移。12例患者向脑、内脏、骨广泛转移,无ER+/PR-。以上四组ER和PR表达状态间差异有统计学意义。结论除了广泛转移组,转移性乳腺癌主要有两种转移方式。ER+/PR+的乳腺癌更容易发生骨转移。ER-/PR-的乳腺癌容易发生脑转移而不易发生骨转移。对其的认知有利于指导放射科医师对转移病灶的检出并帮助临床医师估计乳腺癌转移至各个脏器系统的可能性,同时指导对其进行靶向预防性治疗。
Objective To evaluate tumor hormone receptor status as a predictor of breast cancer spread.Materials and Methods 57 patients were divided into four groups according to the distributions of metastatic disease spread in metastatic breast carcinoma.All patients with confirmed metastatic breast carcinoma,in whom the presence or absence of tumor estrogen and progesterone receptors（ER＋或ER-/PR＋或PR-）was known to perform both MR of the brain and total body skeletal scintigraphy et al,were studied retrospectively.Results Among 28 patients with skeletal metastases without brain metastases,57% were ER＋/PR＋.7 patients had brain metastases without skeletal involvement,71%（5/7） of which were ER-/PR-.10 patients had skeletal metastases and scattered metastases to the chest or abdomen or both without brain metastases.A final group,consisting of 12 patients,showed widespread disease,with diffuse metastases to the brain,viscera,and skeleton,all of them were ER＋/PR-.The tumor receptor status was statistically different between four groups.Conclusion There are two major patterns of disease spread in metastatic breast carcinom,patients with ER＋/PR＋ tumors tend to develop osseous without brain metastases,patients with ER-/PR-tumors tend to develop brain without osseous metastases,recognition of these distributions can aid radiologists to detect metastatic lesions,and will help clinicians to estimate the likelihood of metastases to various organ systems,as well as guide potentially target therapy.
出处
《临床放射学杂志》
CSCD
北大核心
2010年第1期47-50,共4页
Journal of Clinical Radiology
基金
乌鲁木齐市第一批科技开发计划项目资助(编号Y08131008)
关键词
转移性乳腺癌
雌激素受体
孕激素受体
磁共振成像
全身核素骨扫描
Metastatic breast carcinoma Estrogen receptor Progesterone receptor Magntic resonance imaging Body skeletal scintigraphy
