摘要
哺乳动物大脑神经元的形态多样性和突触连接的复杂性是极性细胞的典型例子,形成和维持神经元极性依赖多种极性蛋白的调节。从线虫受精卵发育到哺乳动物神经细胞的极性化通路中,许多极性蛋白存在进化保守机制。中枢神经系统发育的整个过程(包括神经元发生与移行、神经突生长以及突触联系的形成等)都有极性蛋白的直接或间接参与,是各种极性蛋白相互作用/相互制约的动态过程。
The diversity of neuronal morphologies and the complexity of synaptic connections in the mammalian brain provide classical examples for cell polarity.Both the establishment and maintenance of neuronal polarity require the regulation of polarity protein.It is well known that there is a mechanism of evolution conservation for polarity protein from the C.elegans zygote development to mammalian neuronal polarization.The conserved polarity proteins regulate neurogenesis,neurite outgrowth,neuronal migration and synaptogenesis in central nervous system（CNS）.The process of central nervous system development,including neurogenesis,neuronal migration,neurite outgrowth,and synaptogenesis,depends on well-coordinated polarity proteins and reciprocal interaction dynamics.
出处
《国际病理科学与临床杂志》
CAS
2011年第4期296-300,共5页
Journal of International Pathology and Clinical Medicine
基金
国家自然科学基金项目(30825039
30973236
30770748)
四川省科技厅基金(08ZQ026-069)
长江学者和创新团队发展计划(IRT0935)~~
关键词
极性蛋白
中枢神经系统发育
神经发生
轴突形成
突触发生
polarity protein
central nervous system development
neurogenesis
axon outgrowth
synaptogenesis
