摘要
目的:探讨了小儿急性肾炎患儿治疗前后血清IL-2、IL-4和IFN-γ水平的变化及意义。方法:应用放射免疫分析和酶联法对32例急性肾炎患儿进行了治疗前后血清IL-2、IL-4和IFN-γ检测,并与35名正常儿作比较。结果:在治疗前急性肾炎患儿血清IL-4和IFN-γ水平非常显著地高于正常儿组(P<0.01),而IL-2水平又非常显著地低于正常儿组(P<0.01)。经中西医结合治疗3个月后则与正常儿组比较无显著性差异(P>0.05),直线相关分析显示,血清IL-2水平与IL-4、IFN-γ水平呈显著负相关(r=-0.5536、-0.6012,P<0.01)。结论:血清IL-2、IL-4和IFN-γ在急性肾炎患儿的发生和发展过程中相互作用,对观察病情的变化和探讨其发病机理及指导用药均有重要的临床价值。
Objective To explore the clinical evaluation of the changes of determination of serum IL-2,IL-4 and IFN-γ levels after treatment in pediatric patients with acute nephritis.Methods Serum IL-2（with RIA）,IL-4,IFN-γ（with ELISA） levels were determined both before and after treatment in 32 pediatric patients with acute nephritis and 35 normal controls.Results The serum IL-4,IFN-γ levels were significantly higher in the patients than those in controls before treatment（P0.01）,but serum IL-2 levels were markedly lower in the patients（P0.01）.The serum IL-2,IL-4 and IFN-γ levels in patients were no significant difference from those in controls after treatment for 3 months（P0.05）.Serum IL-2 levels were negatively correlated with IL-4,IFN-γ levels（r=-0.5536,-0.6012,P0.01）.Conclusion Interaction of the serum IL-2,IL-4 and IFN-γ also participated in the pathogenesis of acute nephritis in pediatric patients,mornitoring the changes of their serum levels was helpful for the management of the diseases and provider important clinical value.
出处
《放射免疫学杂志》
CAS
2011年第4期378-379,共2页
Journal of Radioimmanology
