摘要
CpG ODN(CpG oligodeoxynucleotides)是一类可模拟细菌DNA免疫活性效应的寡脱氧核苷酸,其生物学功能受自身结构特征影响。特定序列的CpG ODN可通过与破骨细胞前体、前破骨细胞、成骨细胞表面的TLR9结合,调节RANKL、M-CSF、TNF-a、IL-12、TREM-2等细胞因子的表达水平,促进或抑制破骨细胞的形成与分化。本文就CpG ODN对破骨细胞(osteoclast,OC)分化调控作用的研究进展加以综述。
CpG ODN is a kind of oligodeoxynucleotides which simulate the immune activity effect of bacterial DNA. Its biological function is decided by its structure characteristics.Specific CpG ODN can stimulate or inhibit the osteoelastogenesis via the toil-like receptors 9 of OC precursors ,pre-osteoclasts and Osteoblasts by adjusting the level of RANKL, M-CSF, TNF-α, II,-12, TREM-2. The paper reviews introduces current studies about CpG oligodeoxynucleotides and its regulation effect on osteoclast differentiation.
出处
《现代生物医学进展》
CAS
2011年第17期3390-3392,共3页
Progress in Modern Biomedicine
基金
吉林省自然科学基金(201015203)
