摘要
背景:近年来随着微创技术的普及,输卵管介入复通治疗输卵管阻塞已较普遍,但患者术后粘连仍是困扰临床医生的一大难题。目的:总结近年来医用几丁糖凝胶预防输卵管再通术后粘连的应用现状。方法:由第一作者检索1998-02/2011-02万方数据库,以"医用几丁糖凝胶;腹腔镜;治疗;输卵管妊娠"等为检索词,检索几丁糖在输卵管介入再通术中预防术后粘连方面的文献。排除重复研究或较陈旧文献。共保留相关文献30篇进行分析。结果与结论:医用几丁糖是一种具有良好生物相容性、生物可降解性、生物学活性的医用高分子多糖类物质。其具有广谱抑菌作用,选择性促进上皮细胞、内皮细胞生长而抑制成纤维细胞生长的生物学特性,从而促进组织生理性修复,促进切口迅速修复,抑制瘢痕形成,减少组织粘连,具有润滑、生物屏障作用,能有效的阻止粘连发生,促进输卵管功能的恢复,为再次妊娠打下基础。
BACKGROUND： With the popularity of minimally invasive techniques in recent years, tubal recanalization treatment for tubal obstruction has been more common, but postoperative adhesion is still a great trouble for clinicians. OBJECTIVE：To review the application status of chitosan gel in the treatment of adhesion following tubal recanalization. METHODS： The first author retrieved related articles about application of chitosan gel against postoperative adhesion following tubal recanalization published from 1998-02 to 2011-02 using the Keywords of ＂chitosan gel; laparoscopy; treatment; tubal pregnancy＂. Repetitive or old articles were excluded, and finally 30 relevant papers were included. RESULTS AND CONCLUSION： Chitosan is a medical polymer polysaccharide with good biocompatibility, biodegradability and biological activity. With broad-spectrum antimicrobial effect, chitosan selectively promotes the growth of epithelial cells and endothelial cells, and inhibits fibroblast growth, thereby contributing to physiological tissue repair and rapid wound healing, inhibiting scar formation, and reducing tissue adhesion. Because of lubrication and biological barrier effects, chitosan can effectively prevent adhesion occurrence and promote functional recovery of the oviduct to lay the foundation for the subsequent pregnancy.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2011年第29期5413-5416,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
