摘要
目的:运用计算出的AFP及F-βHCG的MOM值与目前采用的MOM值对孕妇进行胎儿神经管缺陷畸形及唐氏综合征筛查,期待能更有效地筛查出南昌地区胎儿神经管缺陷及唐氏综合征高危孕妇。方法:依据2005～2007年到江西省妇幼保健院产前诊断门诊就诊的孕妇各孕周AFP、F-βHCG的中位数,计算出AFP、F-βHCG的MOM值,用计算出的MOM值(研究组)和目前采用的MOM值(对照组)分别对2008年来该院产前诊断门诊就诊的孕妇进行胎儿神经管缺陷畸形及唐氏综合征筛查,对筛查出的高危孕妇进行羊水检测和随访,比较两种MOM值对胎儿神经管缺陷畸形和唐氏综合征筛查的阳性率、假阴性率及假阳性率。结果:神经管缺陷畸形、唐氏综合征阳性率研究组高于对照组,具有统计学意义(P<0.01);假阴性率研究组与对照组比较,结果无统计学意义;假阳性率研究组较对照组降低,结果具有统计学意义,(神经管缺陷畸形P<0.05,唐氏综合征P<0.01)。结论:应用本地区MOM值进行神经管缺陷畸形及唐氏综合征筛查,能更有效地筛查出本地区的神经管缺陷畸形及唐氏综合征胎儿。
Objective：To screen fetal neural tube defect and Down＇s syndrome by calculated MOM values and values currently used of serum alpha-fetoprotein（AFP） and free β human chorionic gonadotropin（F-β HCG） in pregnant women,in order to screen out the high risk pregnant women of fetal neural tube defect and Down＇s syndrome in Nanchang region. Methods：The MOM values of AFP and F-β HCG were calculated according to the medians of AFP and F-β HCG in pregnant women of different gestational weeks who visited the prenatal diagnosis outpatient of the hospital from 2005 to 2007,then the calculated MOM values（study group） and the MOM values currently used（control group） were used to screen fetal neural tube defect and Down＇s syndrome among the pregnant women who visited the prenatal diagnosis outpatient of the hospital in 2008,the high risk pregnant women screened out received amniotic fluid detection and they were followed up;the positive rates,false negative rates and false positive rates of the two kinds of MOM values in screening of fetal neural tube defect and Down＇s syndrome were compared. Results：The positive rates of fetal neural tube defect and Down＇s syndrome in study group were significantly higher than those in control group（P0.01）.There was no significant difference in false negative rates of fetal neural tube defect and Down＇s syndrome between study group and control group;the false positive rates of fetal neural tube defect and Down＇s syndrome in study group were significantly lower than those in control group（neural tube defect： P0.05;Down＇s syndrome： P0.01）. Conclusion：Local MOM values can screen out the local fetuses with neural tube defect and Down＇s syndrome more effectively.
出处
《中国妇幼保健》
CAS
北大核心
2011年第24期3714-3716,共3页
Maternal and Child Health Care of China
