摘要
目的分析原发性血脂异常和2型糖尿病合并血脂异常中医证素的分布规律,以及血脂指标的临床分布特点。方法纳入原发性血脂异常(原脂组)及2型糖尿病合并血脂异常(糖脂组)患者各100例,收集中医四诊信息,观察总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)及高密度脂蛋白胆固醇(HDL-C)指标变化。对数据进行处理,对因子分析结果进行证素分析。同时将2组血脂指标进行对照,探讨临床分布特点。结果 2组病位均以脾、肝、肾为主,但原脂组更偏重于脾,糖脂组肾更突出;病性证素中皆有湿、痰、气滞、血瘀、热、气虚、阴虚、阳虚等,但原脂组以湿、痰、瘀等实性证素为主,糖脂组阴虚、气虚等虚性证素更为突出。2组TC、TG、HDL-C、LDL-C有显著性差异(P<0.05)。结论①原发性血脂异常中医证素以脾、肝、肾,痰湿、气滞、血瘀等为主,治疗应以疏肝健脾、化痰祛湿、活血理气为主,佐以补益肝肾等;2型糖尿病合并血脂异常中医证素以肾、肝、脾,阴虚、气虚为主,治疗应以滋补肝肾、益气养阴为主,佐以化痰祛湿等。②原发性血脂异常以TC、LDL-C升高为主,2型糖尿病合并血脂异常以TG升高及HDL-C降低为主。
Objective To analyze the distribution laws of TCM syndrome factors of primary dyslipidemia and type 2 diabetes complicating dyslipidemia,and clinical distribution characteristics of indexes of blood fat.Methods The information of TCM four examinations were collected from the patients with primary dyslipidemia（primary group） and patients with type 2 diabetes complicating dyslipidemia（diabetes group,each n=100）.The changes of total cholesterol（TC）,triglyceride（TG）,low-density lipoprotein-cholesterol（LDL-C） and high-density lipoprotein-cholesterol（HDL-C） were observed.After the data were treated,the syndrome factors from results of factor analysis were studied.The indexes of blood fat were compared and the distribution characteristics were reviewed in two groups.Results The disease locations mainly included spleen,liver and kidney,and especially spleen in the primary group and kidney in the diabetes group.The syndrome factors of disease nature included dampness,phlegm,qi stagnation,blood stasis,heat,qi deficiency,yin deficiency and yang deficiency,and especially dampness,phlegm and blood stasis in the primary group,and yin deficiency and qi deficiency in the diabetes group.The levels of TC,TG,HDL-C and LDL-C were significantly different（P〈0.05） between two groups.Conclusion ①The TCM syndrome factors of primary dyslipidemia are mainly spleen,liver,kidney,phlegm,dampness,qi stagnation and blood stasis.The therapies are soothing liver and fortifying spleen,resolving phlegm and dispelling dampness,activating blood circulation and regulating qi assisted by replenishing liver and kidney.The TCM syndrome factors of type 2 diabetes complicating dyslipidemia are mainly kidney,liver,spleen,yin deficiency and qi deficiency.The therapies are nourishing liver and kidney,replenishing qi and nourishing yin assisted by resolving phlegm and dispelling dampness.②The increase of TC and LDL-C are mainly changes in primary dyslipidemia,and the increase of TG and decrease of HDL-C are mainly changes in t
出处
《北京中医药大学学报（中医临床版）》
2011年第4期1-5,共5页
Journal of Beijing University of Traditional Chinese Medicine
关键词
血脂异常
2型糖尿病
血脂指标
证素
dyslipidemia
type 2 diabetes
indexes of blood fat
syndrome factors
