摘要
目的观察三氧化二砷(As2O3)联合维生素C对初发急性早幼粒细胞白血病(APL)患者的疗效及不良反应。方法采用随机对照研究观察As2O3联合维生素C(治疗组)及单用As2O3(对照组)治疗初发APL患者的完全缓解率、达完全缓解的时间及两组药物不良反应。结果两组患者完全缓解率皆为95%,治疗组达完全缓解的时间明显小于对照组,差异有统计学意义(P<0.05),而两组的药物不良反应差异无统计学意义(P>0.05)。结论 As2O3联合维生素C用于初发APL患者,疗效更好。
Objective To investigate the efficacy and side effects of arsenic trioxide（As2O3） combined with vitamin C for adult acute promyelocytic leukemia（APL）. Methods In the randomized controlled trials,to observe the complete remission（CR） and the time to CR and adverse effects of treatment group（As2O3） combined with vitamin C） and control group（uses As2O3 only）. Results The complete remission rates of both groups were 95%, the time to CR of treatment group was shorter than the control group, the two groups were obviously different（P〈0.05 ）. The adverse reactions to drug of two groups were not different significantly（P〈0. 05）. Conclusion For adult APL induction with As2 O3 and vitamin C combination can obtain a shorter time to CR.
出处
《中国误诊学杂志》
CAS
2011年第22期5303-5305,共3页
Chinese Journal of Misdiagnostics
