摘要
目的：观察益寿调脂片治疗用药对实验性动脉粥样硬化家兔血脂、一氧化氮（ＮＯ） 和过氧化脂质的影响。方法：将３２ 只新西兰兔随机分为正常组（８ 只） 、造模组（２４ 只） 。正常组喂普通饲料，造模组喂高脂饲料，８ 周后造模组再随机分为模型组、益寿调脂片治疗组（ 加服益寿调脂片，每只每天每ｋｇ 体重４ ｇ） ，舒降之治疗组（ 加服舒降之，每只每天每ｋｇ 体重２－５ ｍｇ） 。用药４ 周后，抽血测生化指标。结果：益寿调脂片能提高超氧化物歧化酶（ＳＯＤ） 的活性，抑制高脂所致的血清ＮＯ降低和脂质过氧化物的升高，降低血清总胆固醇（ＴＣ） 、甘油三酯（ＴＧ） 水平，且提高ＳＯＤ活性方面优于舒降之（ Ｐ＜ ０－０５） ，对升高血清ＮＯ 和降低丙二醛（ＭＤＡ） 方面也优于舒降之，但无统计学意义。结论：益寿调脂片可能通过提高ＳＯＤ、ＮＯ的含量及活性，抑制脂质过氧化物的形成，而起到抗动脉粥样硬化形成的作用。
Aim:To observe the effect of Yishou Tiaozhi Tablet on levels of Serum Lipid,Nitric Oxide (NO),Lipid Peroxide and Superoxide dismudase in atherosclerotic rabbit induced by high cholesterol diet. Methods:Thirty-two male Newzealand rabbits were divided radomly into two groups,group A(8 control)and group B (24 model). Ordinary diet was fed to group A for twelve weeks;to group B,fed cholesterol and Lipid.Eight weeks then, Group B was randomly divided again into three group,group C, group D and E.Cholesterol and Lipid were fed to every group. In group D, Yishou Tiaozhi Tablet ( 4.0 g·kg -1 ·d -1 ) was given for four weeks.In group E,zocor (2.5 mg·kg -1 ·d -1 ) was given,Biochemical parameters were measureed after treated for four weeks.Results:Yishou Tiaozhi Tablet could significantly protect NO and SOD level, decrease MDA content as well as lower the serum levels of total cholesterol and triglyceride.Conclusion:Yishou Tiaozhi tablet has the effect of preventing and treating experiment alatheroscierosis by way of protecting NO and SOD level, decreasing lipid peroxidation.
出处
《暨南大学学报（自然科学与医学版）》
CAS
CSCD
1999年第6期84-87,共4页
Journal of Jinan University(Natural Science & Medicine Edition)
基金
国务院侨办基金!(93 -95- 47)
关键词
益寿调脂片
动脉粥样硬化
血脂
一氧化氮
治疗
Yishou Tiaozhi tablet
atherosclerosis
serum lipid
nitric oxide
lipid peroxidation
