摘要
目的探讨脂质微泡与高分子聚合物超声造影剂在大鼠肠系膜微循环中的流变学特征。方法对10只大鼠经股静脉分别注射DiI标记的脂质微泡和高分子聚合物超声造影剂,通过倒置荧光显微镜观察两种不同造影剂在大鼠肠系膜微循环中的运动情况;比较注射前后小动脉、小静脉及毛细血管内径的变化,测定红细胞与两种造影剂在微循环内的流速。结果注射后两种造影剂在大鼠肠系膜微循环内均可随血流移动,仅见少量脂质微泡短暂滞留。注射造影剂前后小动脉、小静脉及毛细血管内径无明显改变(P>0.05);两种造影剂在微循环内的流速与红细胞相似,差异无统计学意义(P>0.05)。结论脂质微泡和高分子聚合物超声造影剂具有与红细胞相似的微循环流变学特征,均可作为红细胞示踪剂。
Objective To investigate the microvascular rheology characteristics of lipid-and polymer-shelled ultrasound contrast agents in mesentery microcirculation of rats.Methods DiI-stained lipid-and polymer-shelled ultrasound contrast agents were prepared.After injection of the two contrast agents from the femoral vein of 10 rats,the microvascular rheology of the contrast agents in the mesentery microcirculation were observed under the inverted fluorescence microscope.The diameter of the arterioles,venules and capillaries before and after injection were compared.The velocity of the red blood cells and the contrast agents were measured.Results The contrast agents could move with the blood flow in the microcirculation.Only transient retention of few lipid microbubbles was observed in the venules.After injection of the contrast agents,the diameter of the arterioles,venules and capillaries had no significant difference（P0.05）.The velocity of the red blood cells and the two contrast agents had no significant difference（P0.05）.Conclusion Lipid-and polymer-shelled contrast agents have similar microvascular rheology characteristics with red blood cells,both can be used as tracers of red blood cells.
出处
《中国医学影像技术》
CSCD
北大核心
2011年第8期1525-1527,共3页
Chinese Journal of Medical Imaging Technology
基金
国家自然科学基金面上项目(30970752
81071158)
重庆市科技攻关项目(CSTC
2009AB5216)
关键词
造影剂
超声学
微循环
流变学
Contrast media
Ultrasonics
Microcirculation
Rheology
