摘要
苯乙酮衍生物与苯甲醛衍生物缩合可制备各种查尔酮,报道了4种苯乙酮衍生物与9种苯甲醛之间相互缩合的结果,讨论了环上取代基对缩合反应的影响。苯甲醛环上取代基,除羟基外无论是吸电子基还是给电子基对缩合反应收率影响都不大;羟基处于醛基邻位和对位的苯甲醛与几种苯乙酮衍生物的缩合,多数没有得到预期的产物,或收率极低;苯乙酮环上的羟基对缩合反应影响很大,羟基越多,缩合越困难。提出了一种假设,试图解释羟基对缩合反应的影响。
Chalcones can be prepared through condensation of acetophenones with benzaldehydes. The condensation of four acetophenones react with nine derivatives of benzaldehyde especially the effect of substituted groups on the condensation reaction were studied. The groups in ring of benzaldehydes, no matter they are electron withdrowing or electron donating except of hydroxy, do not seem to have much effect on the yield. When hydroxy group lies in para or ortho position of benzaldehyde, some of condensation experiments ended in falure and the others had a very poor yield. The more hydroxy groups has the acetophenone, the more difficultly will the condensation reaction take place. To explain the effect of the groups, a proposal was suggested.$$$$
出处
《合成化学》
CAS
CSCD
1999年第4期422-426,共5页
Chinese Journal of Synthetic Chemistry
基金
甘肃省教委资助!课题 (978- 18)
关键词
查尔酮
苯甲醛
苯乙酮
缩合
Chalcone, Benzaldehyde, Acetophenone, Condensation.
