摘要
近年来的研究表明,内源性逆转录病毒作为哺乳动物基因组的重要组成部分,在与宿主共进化过程中发挥重要作用。对内源性绵羊肺腺瘤病毒的研究,为揭示哺乳动物内源性逆转录病毒与宿主共进化关系提供了一个独特的模型系统。内源性绵羊肺腺瘤病毒在与宿主共进化过程中不断的增强自身的宿主适应性,通过取代宿主原有的促进孕体发育及胎盘形成的机制而发挥作用。通过分析近年来国内外学者对于内源性逆转录病毒一些相关研究,从内源性逆转录病毒在进化中可能的作用、内源性绵羊肺腺瘤病毒的分类、基因结构特点、在与宿主共进化过程中可能的作用、对孕期激素的影响及与外源性绵羊肺腺瘤病毒相互作用关系等方面进行了综述。
Recent studies showed that endogenous retroviruses as an important part of the genome of mammal in the host play an important role during the coevolution.The endogenous Jaagsiekte sheep retrovirus offer a unique model system for studing the coevolution relationship between endogenous betaretroviruses and their host.By replacing the original mechanism for conceptus development and placental development,the endogenous Jaagsiekte sheep retrovirus constantly enhance their own host adaptation.This article simply reveiwed the possible role of endogenous retroviruses during the evolution,the classification of endogenous retroviruses,the genetic structure feature,the function in coevolution,interaction relationship with JSRV.
出处
《动物医学进展》
CSCD
北大核心
2011年第7期72-76,共5页
Progress In Veterinary Medicine
基金
国家自然科学基金项目资助(30960271
30760178)
关键词
内源性绵羊肺腺瘤病毒
共进化
孕体发育
Endogenous Jaagsiekte sheep retrovirus
coevolution
conceptus development
