摘要
本文旨在探讨沙棘脂肪酸组成分对线粒体内膜蛋白辅酶活性与线粒体功能的保护作用,推测其从线粒体能量代谢途径抗衰老的作用机制。采用方法,以沙棘脂肪酸配制成为能量调节剂,以线粒体为调控靶标,观察老年雌性大鼠线粒体内膜蛋白及辅酶成分,呼吸链功能、ATP生成等调节因素对衰老形成的影响。结果表明,沙棘脂肪酸组成分能显著提高复合酶Ⅰ、Ⅲ、ATP合酶、Ca2+-ATP酶活性及P/O、OPR;与老年雌性大鼠组比较差异显著(P<0.05,P<0.01)。因此,沙棘脂肪酸组成分通过调节线粒体内膜蛋白辅酶活性,改善线粒体呼吸功能,促进ATP合成,促进细胞能量转换并激活机体各系统功能来实现抗衰老作用的目的。
The main idea of the article is to explore the function of the composition of seabuckthorn fatty acid on mitochondrial sub-coenzyme activity and the protective effect of mitochondria,so then speculated the mechanism of anti-aging from energy metabolism pathway of the mitochondria.Experimentation： using energy regulator made by seabuckthorn fatty acid,which target is mitochondria,and then observe the effection to aging from the components of mitochondrial proteins,the function of the respiratory chain,ATP synthesis and so on.The results show that the composition of seabuckthorn fatty acid can significantly increase the activity of enzymeⅠ,Ⅲ,ATP synthase,Ca2＋-ATP enzyme,and P/O,OPR;compared with aged female rats the difference is significant（P0.05,P0.01）.So,seabuckthorn fatty acid can anti-aging from regulating the sub-coenzyme of the mitochondria,improving mitochondrial respiratory function,promoting ATP synthesis,energy conversion and activing the function of the body＇s system.
基金
国家十五重大科技专项"创新药物和中药现代化""863"基金资助项目(No.2003AA2Z3980)
关键词
沙棘脂肪酸组成分
线粒体
能量新陈代谢
抗衰老
seabuckthorn fatty acids（SBFAs）
mitochondrion
energy metabolism
anti-aging
