摘要
目的探讨冠心病(CHD)患者幽门螺杆菌(Hp)感染的发生状况及其与血脂代谢的关系。方法采用酶联免疫吸附法检测78例CHD患者及30例健康对照者血清抗Hp抗体及抗Hp细胞毒素相关基因蛋白A(Hp-CagA)抗体水平,分析其阳性率与患者血脂水平的关系。结果冠心病组血清抗Hp抗体及抗Hp-CagA抗体阳性率明显高于健康对照组(P<0.01)。冠心病组中Hp抗体阳性患者血清胆固醇、甘油三酯及低密度脂蛋白包括载脂蛋白A1和载脂蛋白B水平明显高于Hp抗体阴性患者,而高密度脂蛋白却低于Hp抗体阴性患者(P<0.05)。结论 Hp感染可能会通过影响机体脂质代谢,促进动脉粥样硬化(AS)的形成,讲而诱发CHD。
Objective To investigate the infection of helicobacter pylori（Hp） and its relationship to serum lipids in patients with coronary heart disease（CHD）. Methods Serological antibodies of anti-Hp-CagA and anti-Hp were determined in 78 patients with CHD and 30 healthy controls by ELASA assay. The positive rate of Hp and its relationship with the levels of serum lipids were analyzed. Results Anti-Hp and anti-Hp-CagA antibody positive rates in patients with CHD were obviously higher than those in controls （P 〈 0. 01 ）. Serum levels of cholesterol, triglyceride and low density lipoprotein including apolipoprotein A1 and B in anti-Hp positive patients with CHD were higher but high density lipoprotein was lower than those in anti-Hp nagative patients with CHD （ P 〈 0. 05）. Conclusion Hp infection may induce the occurrence of CHD by modifying the serum lipid profile in a way that increases the risk of atherosclerosis.
出处
《中国临床新医学》
2011年第7期612-614,共3页
CHINESE JOURNAL OF NEW CLINICAL MEDICINE
