摘要
分别采用摇床法和流通池法测定罗替戈汀微球的体外释放度,并通过与体内药动学曲线拟合进行选择。结果表明,摇床法和流通池法测定的体外释放度均与体内吸收具有明显相关性,相关系数r分别为0.9937和0.9978,且流通池法可检测到微球存在的较小突释。摇床法和流通池法均可用于罗替戈汀微球的体外释放度检查,流通池法作为一种新型溶出度检测方法,对指导处方筛选有较大意义。
In vitro release of rotigotine microspheres were carried out according to orbital shaker bath method and flow-through cell method,and it was determined by in vitro-in vivo correlations.In vitro release obtained by the orbital shaker bath method and flow-through cell method both had good correlation with in vivo absorption,the correlation coefficients were 0.9937 and 0.9978,respectively.And a small initial burst was detected by the flow-through cell method.The orbital shaker bath method and flow-through cell method can both be used to determine the in vitro release of rotigotine microspheres.The flow-through cell method,as a new method,give more significant results for formulation screening.
出处
《光谱实验室》
CAS
CSCD
北大核心
2011年第4期2025-2027,共3页
Chinese Journal of Spectroscopy Laboratory
关键词
罗替戈汀微球
释放度
摇床法
流通池法
Rotigotine Microspheres
Release
Orbital Shaker Bath Method
Flow-Through Cell Method
