摘要
目的:对比探讨普通血液透析(HD)和高通量血液透析(HFHD)对骨转运指标的影响及其在肾性骨病诊断中的意义,为临床诊断和治疗提供参考。方法:回顾性分析本院2010年1月～2011年1月收治入院的60例由血液透析导致肾性骨病的患者,随机分为两组:观察组30例,行高通量血液透析治疗;对照组30例,行普通血液透析治疗。分别测定各组治疗前后血钙、血磷、甲状旁腺激素(PTH)及β2-微球蛋白(β2-MG)。结果:两组内相比,透析后所有患者各项骨转运指标均优于透析前,比较差异有统计学意义(P<0.05);两组间相比,观察组患者各项骨转运指标均优于对照组,比较差异有统计学意义(P<0.05)。结论:应用HFHD早期治疗,可有效控制患者的血钙、血磷、PTH及β2-MG等骨转运指标,改善血透患者的透析相关性淀粉样变及继发性甲状旁腺功能亢进症状,但HD效果较差,因而HFHD值得在临床中推广使用。
Objective： To compare the effect of common hemodialysis （HD） and high-flux hemodi-alysis （HFHD） transport index on different indices of hone transportation and significance in the diagnosis and treatment of renal osteodystrophy. Methods. A total of 60 cases with renal osteodystrophy due to he modialysis, which were admitted from January 2010 to January 2011 were randomly divided into 2 groups by half. Patients in experimental group were treated by high-flux hemod{alysis, while patients in control group were treated by common hemodialysis. Different indexes including calcium, phosphorus and para thyroid hormone （PTH）, β2 microglobulin （β2 - MG） were measured before and after treatment. Re- suits. After treatment, all indicators were improved and the difference was statistically significant （P〈0.05）. And the improvement was more significantlysatisfactory in experimental group than those in the control group （P〈0.05）. Conclusions：With early HFHD treatment,serum calcium,phosphorus,parathyroid hormone （PTH）,β2-microglobulin （β2-MG） and other indicators of bone transportation can be controlled effectevely.Symptoms of dialysis starch degeneration and secondary hyperparathyroidism can be improved.But HD is less effective.HFHD is worthy extensive clinical application.
出处
《海南医学院学报》
CAS
2011年第8期1129-1131,共3页
Journal of Hainan Medical University
基金
海南医学院科研基金资助学报项目(0020110292)~~
关键词
普通血液透析
高通量血液透析
肾性骨病
骨转运指标
Common hemodialysis
High-flux hemodialysis
Renal osteodystrophy
Bone trans-portation indicators
