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微小RNA与垂体腺瘤发病机制的相关研究进展 被引量:4

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摘要 微小RNA(miRNA)作为一种新的遗传物质,是近年分子生物学研究的热点之一,其与肿瘤发病机制的研究越来越深入。miRNA是一类长度约21~25个核苷酸的内源性非编码RNA,主要与靶基因的3'非翻译区结合,并参与基因的转录后表达。而垂体腺瘤是一种常见颅内肿瘤,发病率仅次于胶质瘤、脑膜瘤,约占颅内肿瘤的15%。近年研究发现:miRNA参与垂体腺瘤的细胞增殖、分化、凋亡,与肿瘤发生、发展密切相关。本文主要介绍miRNA在垂体腺瘤发病机制中的研究进展。
出处 《中国微侵袭神经外科杂志》 CAS 北大核心 2011年第7期329-332,共4页 Chinese Journal of Minimally Invasive Neurosurgery
基金 上海市自然科学基金(编号:Z08ZR1413)
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同被引文献45

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