摘要
以白蛋白为载体的紫杉醇纳米粒在抗肿瘤方面发挥了重要作用。本文对紫杉醇白蛋白纳米粒体内药动学过程、纳米粒转运机制进行探讨,并就近几年来紫杉醇白蛋白纳米粒在乳腺癌、非小细胞肺癌及其他恶性肿瘤方面的临床研究作一综述,为临床应用提供借鉴。
Albumin is a vital drug carrier for nanoparticle paclitaxel in the anti-cancer treatment.This paper reviewed the pharmacokinetics and mechanism of nanoparticle transport of nanoparticle albumin-bound paclitaxel,and summarized the recent clinical trials of nanoparticle albumin-bound paclitaxel in breast cancer,non-small cell lung cancer,and other malignant treatment which could be a reference for its clinical use.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2011年第6期716-720,共5页
Chinese Journal of Clinical Pharmacology and Therapeutics
关键词
紫杉醇
白蛋白纳米粒
临床研究
Paclitaxel
Nanoparticle albumin-bound
Clinical trial
