摘要
目的:对比观察小剂量咪达唑仑单用和其与丙泊酚联合应用在无痛胃镜检查中的效果。方法:对行无痛胃镜检查患者200例,随机分为2组:咪达唑仑联合丙泊酚静脉注射(联用组)100例与单用咪达唑仑静脉注射(单用组)100例。记录患者的不良反应发生情况及平均动脉血压(MAP)、心率(HR)、呼吸频率(RR)、脉搏氧饱和度(SpO2)。结果:联用组流延、恶心、呕吐、躁动、咳嗽、咽部不适较单用组显著减少(P<0.05)。胃镜检查后联用组HR、MAP、RR均显著低于单用组(P<0.05),2组SpO2比较无显著差异(P>0.05)。结论:在无痛胃镜检查中小剂量咪达唑仑联合丙泊酚效果优于单用咪达唑仑。联用组能消除患者的痛苦,减少不良反应发生,虽然HR、MAP、SpO2、RR有所下降,但均在安全范围,无需干预治疗,可顺利完成操作。
Objective：To study the effect of low dose of midazolam alone and midazolam combined with propofol in the treatment of painless gastroscopy.Methods：A total of 200 patients were randomly divided into two groups,midazolam in low dosage combined with propofol intravenous（the alone group） of 100 cases with midazolam in low dosage（the combination group） of 100 cases.Adverse reactions,mean arterial pressure（MAP）,heart rate（HR）,respiratory rate（RR） and oxygen saturation（SpO2） were monitored.Results：Nausea,vomiting,restlessness,cough and throat discomfort in the combination group significantly decreased compared within the alone group（P0.05）.HR,MAP,RR in the combination group were lower than the alone group（P0.05） after gastroscopy,SpO2 of the two groups was no significant difference（P0.05）.Conclusions：Midazolam in low dosage combined with propofol in painless gastroscopy superior to a midazolam in low dosage in patients,it can eliminate pain,reduce the incidence of adverse reactions,although the HR,MAP,SpO2,RR decreas,but are safe without intervention,successfully complete the operation.
出处
《中国临床医学》
2011年第3期355-357,共3页
Chinese Journal of Clinical Medicine
