摘要
目的探讨老年高血压病患者血清脂联素(APN)与白细胞介素-6(IL-6)、超敏C反应蛋白(hs-CRP)的相关性。方法选择老年高血压病患者(高血压病组64例,其中高血压1级亚组23例,2级亚组21例,3级亚组20例)。老年健康体检者(健康对照组25例),采用酶联免疫法测定APN、IL-6水平,免疫比浊法测定hs-CRP水平。结果高血压病组APN浓度[(7.8±5.6)mg/L]低于健康对照组[(9.9±3.3)mg/L](P<0.05),而IL-6水平[(59.9±7.5)ng/ml]、hs-CRP水平[(5.9±2.0)mg/L]高于健康对照组[分别为(18.7±5.4)ng/ml和(2.4±1.4)mg/L],差异均有统计学意义(P<0.05);且高血压2级、3级亚组与1级亚组比较差异亦有统计学意义(P<0.05)。相关性分析表明,APN与IL-6、hs-CRP呈负相关(分别为r=-0.577,P<0.05;r=-0.582,P<0.05)。结论老年高血压病患者的APN降低,IL-6、hs-CRP升高,APN与IL-6、hs-CRP呈负相关。
Objective To investigate the relationship between the adiponectin（APN） and hs-CRP,IL-6 in elderly patients with essential hypertension.Methods Sixty-four elderly patients with essential hypertension were enrolled the study, including 23 cases with grade 1,21 cases with grade 2,and 20 cases with grade 3,other 25 healthy elderly people were enrolled as control group.The serum levels of APN,IL-6 were measured with ELISA method,and the serum level of hs-CRP were detected by immunonephelometric method.The relationship between their levels were compared and analyzed.Results The serum levels of APN in elderly patients with essential hypertension group[（7.8±5.6）mg/L]was lower than that in control health elderly group[（9.9±3.3） mg/l]（P0.05 ）.However,the serum levels of IL-6[（59.9±7.5） ng/ml]and hsCRP[（5.9±2.0）mg/L]were higher than that in healthy elderly group[（18.7±5.4） ng/ml,（2.4±1.4）mg/L,respectively, P0.05].Furthermore,the hypertension with grade 2,3 were more obvious than that in hypertension with grade 1 （P0.05）.The relationship analysis demonstrated that the serum levels of APN and,IL-6,hs-CRP had negative correlation （r= -0.577,P0.05;r = -0.582,P0.05,respectively）.Conclusion The serum level of APN decreased in elderly patients with essential hypertension,and the serum level of IL-6 and hs-CRP increased.The serum levels of APN was negative related to the levels of IL-6 and hs-CRP.
出处
《疑难病杂志》
CAS
2011年第7期487-489,共3页
Chinese Journal of Difficult and Complicated Cases
