摘要
目的探讨各因素对心脑血管病死亡的影响和作用强度及各因素在不同年龄段作用的差异。方法对11008名人群进行基线调查，随访8年，应用Cox回归分析各因素对心脑血管病死亡的预测价值。结果心脑血管病死亡事件的发生与脑卒中史、吸烟、收缩压（SBP）、舒张压（DBP）、年龄有关。40～59岁人群主要危险因素相对危险度分别为：脑卒中史（4．903）、DBP每增加10mmHg（1．366，1mmHg=0．133kPa）、吸烟（1．157）、年龄每增加1岁（1．098）；60～74岁人群分别为：脑卒中史（2．405）、吸烟（1．231）、SBP每增加10mmHg（1．201）、体重指数每增加1（1．141）、年龄每增加1岁（1．095）；≥75岁人群：仅年龄每增加1岁（1．068）有统计学意义。结论各因素对心脑血管病死亡的预测价值在不同年龄段是不同的，不同年龄段的人群应侧重于不同的危险因素的预防与控制。
Objective To explore the factors influencing eardio-eerebro vascular death events among people over 40 years of age in Shandong area,China. Methods Baseline survey was carried out in 1991. A total number of 11 008 adults over 40 years old had been studied in Shandong province. Data on cardio eerebro death was collected. The correlation between influencing factors and eardio-cerebro vascular death events was analyzed by Cox regression model. Results Totally,434 eardio-cerebro death events occurred among the 11 008 subjects during the 8-year follow-up study. Cardio-eerebro death events were related to systolic blood pressure, diastolic blood pressure, smoking, stroke history and age. Data from Cox regression analysis showed that the relative risk（ RR ） for eardio-cerebro vascular death events increased by 2. 862 [95 % confidence interval（ CI）：1, 976-4. 144] times for those people having stroke history. When systolic blood pressure, diastolic blood pressure increased by every 10 mm Hg, the relative risk for cardio-eerebro vascular death events increased by 1.171（95% CI： 1.033-1.328）, 1.214（95% CI： 1.044- 1.413） respectively, it was found that a 1. 239（95 % CI ： 1. 088-1. 553） times higher in smokers than non-smokers on relative risk for cardio-cerebro vascular death events. However, the predictive values of the influencing factors for cardio-cerebro vascular death were different among population of different years of age. The relative risk for cardio-cerebro vascular death events increased by 1. 366 （95 % CI ： 1. 102-1. 678） times for each 10 mm Hg increase of diastolic blood pressure in 40-59 years old population. However, the effect was taken place by systolic blood pressure in 60-74 years old population, with a relative risk of 1. 201（95 % CI： 1,017-1.418） for each 10 mm Hg increase. Age seemed the only significant factor for cardio-cerebro vaseular death events on population aged more than 75 years old. Conclusion The predictive values of the risk factors were different am
出处
《中华流行病学杂志》
CAS
CSCD
北大核心
2007年第2期119-122,共4页
Chinese Journal of Epidemiology
关键词
血压
心脑血管病
死亡事件
危险因素
Blood pressure
Cardio-cerebro vascular disease
Death incident
Risk factor
