摘要
目的探讨老年乳腺癌不同分子亚型的临床特点及其预后情况。方法回顾性分析手术治疗的原发性乳腺癌172例老年乳腺癌患者临床,根据雌激素受体(ER)、孕激素受体(PR)及人类表皮生长因子受体2(HER-2)的免疫组织化学结果,将172例老年乳腺癌分为5种分子亚型:luminal A型[ER(+)和/或PR(+)且HER-2(-)]l、uminal B型[ER(+)和/或PR(+)且HER-2(+)]、HER-2过表达型[ER(-)、PR(-)且HER-2(+)]、三阴性[ER(-)、PR(-)且HER-2(-)]和未知分型,分析不同亚型的临床特点及预后情况。结果 luminal A型l、uminal B型、HER-2过表达型、三阴性和未知分型所占的比例分别为65.7%、7.6%、14.0%、7.6%和5.1%。肿瘤>2 cm及组织学分级III的乳腺癌在三阴性中的比例明显大于其他类型(P<0.05)。170例中位随访时间48个月,结果显示,HER-2过表达型和三阴性乳腺癌的远处转移率均高于luminal A型(P<0.05)。多因素分析显示肿瘤大小和脉管浸润情况为老年乳腺癌的独立预后因素。结论老年乳腺癌分子分型对患者预后的判断具有重要临床意义,可以为老年乳腺癌患者的个性化治疗提供重要依据。
Objective To analyze the relationship of clinicopathological features and prognosis of breast cancer with different molecular subtypes in the elderly.Methods Data of 172 patients aged greater than 65 years old underwent surgery for primary breast cancer were retrospectively analyzed.Based on estrogen receptor(ER) and progesterone receptor(PR) reported by immunohistochemistry,molecular subtypes of breast cancers were categorized as luminal A[ER(+) and/or PR(+) and HER-2(-)],luminal B[ER(+) and/or PR(+) and HER-2(+)],HER-2 overexpressing subtype[ER(-),PR(-) and HER-2(+)],triple negative subtype[ER(-),PR(-) and HER-2(-)]and unknown type.Results The percentages of luminal A,luminal B,HER-2 overexpressing subtype,triple negative subtype and unknown type were 65.7%,7.6%,14.0%,7.6% and 5.1%,respectively.The proportion of tumor size greater than 2 cm and pathologically grading Ⅲ was more in the triple negative molecular subtyp than that in the other subtypes(P<0.05).The results of 170 cases received average 48 months follow-up showed that the distant metastasis rate was higher in the subtypes of HER-2 overexpressing and triple negative than that in luminal A subtype(P<0.05).Multivariate analysis revealed that the tumor size and vessel invasive status were the independent prognostic factors.Conclusion Molecular subtyping could provide important information in predicting the prognosis and guiding the treatment of breast cancer in the elderly.
出处
《江苏医药》
CAS
CSCD
北大核心
2011年第13期1554-1557,共4页
Jiangsu Medical Journal
关键词
乳腺癌
预后
雌激素受体
孕激素受体
人表皮生长因子受体2
Breast cancer
Prognosis
Estrogen receptor
Progesterone receptor
Human epidermal growth factor receptor-2
