摘要
采用膜乳化法结合液中干燥法制备了克拉霉素乙基纤维素微球,当膜孔径为2.8及5.4μm、乙基纤维素浓度为5%～6%及投药量为1∶2时,制得的克拉霉素乙基纤维素微球的载药量、包封率及收率均最高.考察了克拉霉素乙基纤维素微球的缓控释性能,结果表明:膜乳化法制得的克拉霉素乙基纤维素微球的缓控释效果明显优于溶剂挥发法,且膜孔径为5.4μm时制备的克拉霉素乙基纤维素微球的缓控释性能优于2.8μm.
Clarithromycin ethyl cellulose microsphere was prepared by Membrane emulsification combining with liquid desiccation.The load charge mass,encapsulate rate,and yield rate of Clarithromycin ethyl cellulose microsphere could reach the highest level when the membrane aperture was 2.8 and 5.4 μm,the EC concentration was 5%～6%,and the ratio of reagent was 1∶2.The relaxed controlled release property of Clarithromycin ethyl cellulose microsphere suggests that the utilization of membrane emulsification to prepare Clarithromycin ethyl cellulose microspheres is better than that of solvent volatilization in terms of relaxed controlled release effect.Moreover,the effect of membrane aperture 5.4 μm to relaxed controlled release is better than that of membrane aperture 2.8 μm.
出处
《分子科学学报》
CAS
CSCD
北大核心
2011年第3期175-179,共5页
Journal of Molecular Science
基金
国家自然科学基金资助项目(21076026)
辽宁省自然科学基金资助项目(20102005)
辽宁省教育厅重点实验室资助项目(LS2010002)
关键词
膜乳化
克拉霉素
微球
缓控释
membrane emulsification
Clarithromycin
microspheres
sustained or controlled release
