摘要
用合成的N-十六酰-L-组氨酸与用乙醇-水(V乙醇∶V水=1∶1)混合溶剂溶解的水杨酸制成水凝胶,通过X射线衍射和药物缓释实验研究了该水凝胶的性能。结果表明,制得的水凝胶是一种很好的药物载体,且在pH=7时凝胶的稳定性最好。在pH=7.41的缓冲溶液中,水杨酸呈现较好的缓释效果;在偏碱性(pH=10.00)的缓冲溶液中,药物缓释过快,且凝胶不稳定,易松散溶解;在偏酸性(pH=4.04)的缓冲溶液中,释放率稍偏低。低浓度(5 mg/mL)的N-十六酰-L-组氨酸水凝胶和适宜的温度(37℃)有利于水杨酸的释放。
A hydrogel was prepared using synthesized N-palmitoyl-L-histidine and salicylic acid dissolved in mixed solvent of ethanol/water with volume ratio of 1:1.The performances of the hydrogel were investigated by X-ray diffraction(XRD) and the experiments of drug release.The results showed that the hydrogel was an excellent drug carrier and had the best stability at pH=7.The effects of sustained release of salicylic acid were better in the buffer solution with pH=7.41.The drug release was rapid and the hydrogel was instable and easy to loosen and dissolve in the buffer solution with pH=10.00.The rate of drug release was lower in the buffer solution wiht pH=4.04.Salicylic acid was released effectively at 37 ℃ with the low concentration(5 mg/mL) of N-palmitoyl-L-histidine in hydrogel.
出处
《精细石油化工进展》
CAS
2013年第1期55-58,共4页
Advances in Fine Petrochemicals
基金
江西省教育厅科学技术研究项目(GJJ10234)
江西省自然科学基金(20111522040195
2010GZH0018)
江西省高校应用化学与化学生物学重点验室项目(GJJ11707)
关键词
水凝胶
组氨酸
药物缓释
水杨酸
hydrogel
N-palmitoyl-L-histidine
drug release
salicylic acid
