摘要
聚合物用作药物控制释放载体时,具有释药浓度可控、药物的生物利用度高、可实现靶向治疗等优点。但有些聚合物存在机械强度低、化学稳定性差和生物相容性不理想等缺点。二氧化硅(SiO2)具有多孔、无毒、生物相容性好、化学和机械稳定性高、表面易功能化等优点,但SiO2用作药物控制释放载体时,也存在载药量低、不能装载大分子药物、不能实现靶向释放等缺点。聚合物/SiO2杂化材料作为药物控制释放载体,可有效结合二者的优点,并克服二者的缺陷。根据聚合物的种类和杂化体系性质的不同,本文分别对温敏性聚合物/SiO2杂化材料、聚电解质/SiO2杂化材料、生物高分子/SiO2杂化材料以及其他一些聚合物/SiO2杂化材料体系在药物控制释放中的应用进行了介绍,并展望了该领域今后的研究发展方向。
Polymer carriers for drug release have the advantages such as controlled concentration of the released drug, high drug bioavailability in organism and targeting therapy. However, some polymers have disadvantages such as low mechanical strength, poor chemical stability and undesirable biocompatibility. Silica is porous and non-toxic and possesses advantages such as good biocompatibility, high chemical and mechanical stabilities and easy surface functionalization. But for some silica carriers, it is difficult to load large drug molecules, have high drug loading or achieve targeting therapy. Polymer-silica hybrid materials may combine the advantages of polymer and silica carriers in drug delivery and eliminate their disadvantages. Based on the properties of the polymers and the functions of the polymer/ silica hybrid materials, controlled drug release systems, including temperature-sensitive polymer/silica, polyelectrolyte/ silica, biopolymer/silica, and other polymer/silica hybrid materials are reviewed in this article. The research trends of this field are also briefly discussed.
出处
《化学进展》
SCIE
CAS
CSCD
北大核心
2009年第12期2689-2695,共7页
Progress in Chemistry
基金
国家自然科学基金项目(No.50703006)
武汉市科技局晨光计划(No.200750731275)
湖北省教育厅重大项目(No.Z200710001)资助
