摘要
目的探讨血清同型半胱氨酸(Hcy)对皮质下动脉硬化性脑病(BD)的影响及与其严重程度之间的关系。方法测定50例符合Bennett BD诊断标准的住院病人(BD组)血Hcy等生化指标,并与42例健康患者(对照组)比较,分析血Hcy与BD及其Coto分型之间的关系。BD诊断符合Bennett诊断标准,所有患者根据头脑磁共振成像按Coto以病变部位及病变程度分为轻、中、重三型。结果与对照组比较,BD组血Hcy平均水平为(19.46±6.52)μmol/L,明显高于对照组(8.47±4.36)μmol/L(P<0.01),轻、中、重三型间比较有统计学意义(P<0.05),Hcy随BD严重程度而增高。结论 Hcy浓度与BD的发生发展有关,可作为判断BD病情轻重、估计预后的一个参考指标。
Objective To investigate the effects of plasma homocysteine on Binswanger＇s disease.Methods According to the Bennett＇s diagnostic criteria and Coto＇s classification of Binswanger＇s disease,50 hospitalized patients with Binswanger＇s disease and 42 healthy people were collected.The plasma levels of homocysteine were measured among Binswanger＇s disease patients and control group.Results Mean plasma total homocysteine level was higher in BD patients than in controls（19.46±6.52 μmol/L versus 8.47±4.36 μmol/L,P0.01）,they were significantly higher than the control group,and were positively related to the severity of Binswanger＇s disease（P0.01）.Conclusion The increasing serum homocysteine may play an important role in the formation and progression of Binswanger＇s disease,and could be used as a reference index of the severity and prognosis of Binswanger＇s disease.
出处
《中国实用神经疾病杂志》
2011年第12期14-15,共2页
Chinese Journal of Practical Nervous Diseases
